ASSESSMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I CHAIN-RELATED A (MICA) MOLECULE LEVELS IN INTENSIVE CARE UNIT PATIENTS WITH CLOSTRIDIAL INFECTION
Background. The genes of the MIC locus discovered at the end of the 20th century are characterized by high polymorphism. They play an important role in the processes of intercellular interaction, participate in the implementation of innate and adaptive immunity reactions as ligands for the NKG2D rec...
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| Vydáno v: | Zhurnal Grodnenskogo gosudarstvennogo medit͡s︡inskogo universiteta Ročník 23; číslo 4; s. 342 - 346 |
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| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
01.09.2025
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| ISSN: | 2221-8785, 2413-0109 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | Background. The genes of the MIC locus discovered at the end of the 20th century are characterized by high polymorphism. They play an important role in the processes of intercellular interaction, participate in the implementation of innate and adaptive immunity reactions as ligands for the NKG2D receptors expressed on various subpopulations of T-lymphocytes. MICA can be released from the surface of tumor and infected cells after proteolytic cleavage, yielding soluble MICA (sMICA) in serum. MICA is normally detected in low amounts on the surface of endothelial cells fibroblasts monocytes syncytiotrophoblast and epithelial cells especially in the gastrointestinal tract. However this expression increases during stress conditions. Objective. To determine the nature of MICA expression in the intestinal mucosa using immunohistochemistry, as well as the level of sMICA in the blood serum using enzyme immunoassay in patients of the Anesthesiology and Intensive Care Units with clostridial infection induced by antibacterial drugs of the carbapenem group. Results. When assessing the marker expression in biopsy material of patients with clostridial infection and a group without colon pathology, a more pronounced reaction in the mucosa was observed in patients with clostridial infection. When analyzing sMICA indicators, the following results were obtained: the median value was 35.4 ng / ml; 95% confidence interval 105.6-162.7; 25-75% percentile 25.9-66.1. Conclusions. The level of MICA in the blood serum, as well as in the colonic mucosa, in patients with clostridial infection of the AIC units increases when compared with the control group. |
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| ISSN: | 2221-8785 2413-0109 |
| DOI: | 10.25298/2221-8785-2025-23-4-342-346 |