Acetaminophen Inhibits Fatty Infiltration without Impairing Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Repair
Background: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional im...
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| Published in: | Clinics in orthopedic surgery Vol. 17; no. 6; pp. 1015 - 1024 |
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| Format: | Journal Article |
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대한정형외과학회
01.12.2025
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| ISSN: | 2005-291X, 2005-4408 |
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| Abstract | Background: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional impairment. While acetaminophen (APAP) is widely used for pain management, its potential effects on muscle fatty infiltration and tendon-bone interface (TBI) healing remain unclear. This study aimed to investigate whether APAP influences fatty infiltration and TBI healing after RC surgery. We hypothesized that APAP would reduce fatty infiltration by downregulating peroxisome proliferator-activated receptor gamma (PPAR-γ) while preserving histological and biomechanical TBI integrity.
Methods: A RC repair rat model was created using 12-week-old male Sprague-Dawley rats. Ten rats in the APAP group received an oral dose of 30 mg/kg APAP daily for 4 weeks after RC tendon transection, and 10 rats in the control group were administered only 0.9% saline. All rats were sacrificed 4 weeks after surgery. Fatty infiltration was analyzed qualitatively and quantitatively in the proximal part of the supraspinatus muscle. TBI was evaluated for RC healing effect through general tissue staining and biomechanical strength measurements.
Results: Four weeks after tendon repair, the APAP group showed significant prevention of supraspinatus fatty infiltration compared to the control group (p < 0.001). These results were confirmed through immunohistochemical results showing that PPAR-γ, a marker gene for fatty infiltration, was significantly decreased in the APAP group (p < 0.001). Histological healing assessments between the 2 groups were not significantly different (p = 0.634). Additionally, mechanical strength was not negatively affected.
Conclusions: APAP treatment was associated with prevention of supraspinatus fatty infiltration without adversely affecting TBI healing in an RC repair model. KCI Citation Count: 0 |
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| AbstractList | Background: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional impairment. While acetaminophen (APAP) is widely used for pain management, its potential effects on muscle fatty infiltration and tendon-bone interface (TBI) healing remain unclear. This study aimed to investigate whether APAP influences fatty infiltration and TBI healing after RC surgery. We hypothesized that APAP would reduce fatty infiltration by downregulating peroxisome proliferator-activated receptor gamma (PPAR-γ) while preserving histological and biomechanical TBI integrity.
Methods: A RC repair rat model was created using 12-week-old male Sprague-Dawley rats. Ten rats in the APAP group received an oral dose of 30 mg/kg APAP daily for 4 weeks after RC tendon transection, and 10 rats in the control group were administered only 0.9% saline. All rats were sacrificed 4 weeks after surgery. Fatty infiltration was analyzed qualitatively and quantitatively in the proximal part of the supraspinatus muscle. TBI was evaluated for RC healing effect through general tissue staining and biomechanical strength measurements.
Results: Four weeks after tendon repair, the APAP group showed significant prevention of supraspinatus fatty infiltration compared to the control group (p < 0.001). These results were confirmed through immunohistochemical results showing that PPAR-γ, a marker gene for fatty infiltration, was significantly decreased in the APAP group (p < 0.001). Histological healing assessments between the 2 groups were not significantly different (p = 0.634). Additionally, mechanical strength was not negatively affected.
Conclusions: APAP treatment was associated with prevention of supraspinatus fatty infiltration without adversely affecting TBI healing in an RC repair model. KCI Citation Count: 0 |
| Author | Kim, Jun-Young Chung, Seok Won Cho, Chul-Hyun Yoon, Jong Pil Kim, Dong-Hyun Choi, Yoon Seong Lee, Hyun Joo Park, Sung-Jin |
| Author_xml | – sequence: 1 givenname: Jong Pil orcidid: 0000-0001-6446-6254 surname: Yoon fullname: Yoon, Jong Pil organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 2 givenname: Sung-Jin orcidid: 0009-0008-6869-0788 surname: Park fullname: Park, Sung-Jin organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 3 givenname: Dong-Hyun orcidid: 0000-0001-9078-5953 surname: Kim fullname: Kim, Dong-Hyun organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 4 givenname: Yoon Seong orcidid: 0009-0006-1483-0023 surname: Choi fullname: Choi, Yoon Seong organization: Department of Carbon Hybrid Fiber Science, Kyungpook National University, Daegu, Korea – sequence: 5 givenname: Hyun Joo orcidid: 0000-0003-2837-3434 surname: Lee fullname: Lee, Hyun Joo organization: Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 6 givenname: Jun-Young orcidid: 0000-0003-4700-3041 surname: Kim fullname: Kim, Jun-Young organization: Department of Orthopedic Surgery, Daegu Catholic University School of Medicine, Daegu, Korea – sequence: 7 givenname: Chul-Hyun orcidid: 0000-0003-0252-8741 surname: Cho fullname: Cho, Chul-Hyun organization: Department of Orthopedic Surgery, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea – sequence: 8 givenname: Seok Won orcidid: 0000-0002-8221-9289 surname: Chung fullname: Chung, Seok Won organization: Department of Orthopedic Surgery, Konkuk University Medical Center, Seoul, Korea |
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| Cites_doi | 10.1016/j.arthro.2014.08.017 10.1016/j.jse.2014.02.021 10.1016/j.otsr.2016.11.003 10.1007/s00210-023-02937-0 10.1016/j.arthro.2021.11.028 10.5397/cise.2023.00969 10.5397/cise.2023.00850 10.1016/j.arthro.2020.04.016 10.5397/cise.2023.00430 10.5397/cise.2023.00941 10.1016/j.arthro.2007.01.023 10.1177/0363546517744219 10.5397/cise.2022.01417 10.1186/s13018-023-04163-z 10.1136/bmj.j5790 10.1016/j.jse.2021.05.018 10.1016/j.jsams.2013.07.008 10.1016/j.arthro.2024.01.027 10.5397/cise.2024.00010 10.1016/j.arthro.2022.01.040 10.1016/j.jos.2023.11.011 10.2106/00004623-200402000-00002 10.1038/s41598-022-05608-x 10.1007/s10237-016-0776-3 10.1080/23328940.2021.1886392 10.1016/j.jse.2022.05.004 |
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| References | Galatz (10.4055/cios24500_ref6) 2004; 86 Choi (10.4055/cios24500_ref23) 2014; 23 Tangtiphaiboontana (10.4055/cios24500_ref11) 2021; 30 Morrill (10.4055/cios24500_ref19) 2016; 15 Lee (10.4055/cios24500_ref26) 2020; 36 Sasanuma (10.4055/cios24500_ref2) 2024; 29 Vervaecke (10.4055/cios24500_ref22) 2022; 31 Zumstein (10.4055/cios24500_ref21) 2017; 103 Ayoub (10.4055/cios24500_ref16) 2021; 8 Caro (10.4055/cios24500_ref28) 2014; 53 Daher (10.4055/cios24500_ref1) 2024; 27 Gumina (10.4055/cios24500_ref4) 2023; 26 Jung (10.4055/cios24500_ref9) 2024; 27 Radhakrishnan (10.4055/cios24500_ref7) 2024; 27 Akelman (10.4055/cios24500_ref8) 2022; 38 Shinohara (10.4055/cios24500_ref3) 2022; 12 Wang (10.4055/cios24500_ref24) 2023; 26 Goel (10.4055/cios24500_ref15) 2023; 15 Jildeh (10.4055/cios24500_ref30) 2022; 38 Yoon (10.4055/cios24500_ref5) 2024; 27 Oh (10.4055/cios24500_ref12) 2018; 46 Walker (10.4055/cios24500_ref14) 2024; 27 Lu (10.4055/cios24500_ref13) 2015; 95 Yoon (10.4055/cios24500_ref17) 2023; 18 Rubino (10.4055/cios24500_ref25) 2007; 23 Ji (10.4055/cios24500_ref10) 2015; 31 Fearon (10.4055/cios24500_ref20) 2014; 17 Yoon (10.4055/cios24500_ref18) 2024; 40 Sahin (10.4055/cios24500_ref27) 2024; 397 Brat (10.4055/cios24500_ref29) 2018; 360 |
| References_xml | – volume: 31 start-page: 118 issue: 1 year: 2015 ident: 10.4055/cios24500_ref10 publication-title: Arthroscopy doi: 10.1016/j.arthro.2014.08.017 – volume: 23 start-page: 1675 issue: 11 year: 2014 ident: 10.4055/cios24500_ref23 publication-title: J Shoulder Elbow Surg doi: 10.1016/j.jse.2014.02.021 – volume: 103 start-page: S1 issue: 1S year: 2017 ident: 10.4055/cios24500_ref21 publication-title: Orthop Traumatol Surg Res doi: 10.1016/j.otsr.2016.11.003 – volume: 397 start-page: 5067 issue: 7 year: 2024 ident: 10.4055/cios24500_ref27 publication-title: Naunyn Schmiedebergs Arch Pharmacol doi: 10.1007/s00210-023-02937-0 – volume: 38 start-page: 1077 issue: 4 year: 2022 ident: 10.4055/cios24500_ref30 publication-title: Arthroscopy doi: 10.1016/j.arthro.2021.11.028 – volume: 27 start-page: 361 issue: 3 year: 2024 ident: 10.4055/cios24500_ref5 publication-title: Clin Shoulder Elb doi: 10.5397/cise.2023.00969 – volume: 27 start-page: 496 issue: 4 year: 2024 ident: 10.4055/cios24500_ref14 publication-title: Clin Shoulder Elb doi: 10.5397/cise.2023.00850 – volume: 36 start-page: 2080 issue: 8 year: 2020 ident: 10.4055/cios24500_ref26 publication-title: Arthroscopy doi: 10.1016/j.arthro.2020.04.016 – volume: 15 start-page: e48750 issue: 11 year: 2023 ident: 10.4055/cios24500_ref15 publication-title: Cureus – volume: 26 start-page: 323 issue: 3 year: 2023 ident: 10.4055/cios24500_ref4 publication-title: Clin Shoulder Elb doi: 10.5397/cise.2023.00430 – volume: 27 start-page: 519 issue: 4 year: 2024 ident: 10.4055/cios24500_ref9 publication-title: Clin Shoulder Elb doi: 10.5397/cise.2023.00941 – volume: 23 start-page: 717 issue: 7 year: 2007 ident: 10.4055/cios24500_ref25 publication-title: Arthroscopy doi: 10.1016/j.arthro.2007.01.023 – volume: 46 start-page: 679 issue: 3 year: 2018 ident: 10.4055/cios24500_ref12 publication-title: Am J Sports Med doi: 10.1177/0363546517744219 – volume: 26 start-page: 10 issue: 1 year: 2023 ident: 10.4055/cios24500_ref24 publication-title: Clin Shoulder Elb – volume: 27 start-page: 79 issue: 1 year: 2024 ident: 10.4055/cios24500_ref7 publication-title: Clin Shoulder Elb doi: 10.5397/cise.2022.01417 – volume: 18 start-page: 674 issue: 1 year: 2023 ident: 10.4055/cios24500_ref17 publication-title: J Orthop Surg Res doi: 10.1186/s13018-023-04163-z – volume: 53 start-page: 185 issue: 2 year: 2014 ident: 10.4055/cios24500_ref28 publication-title: J Am Assoc Lab Anim Sci – volume: 360 start-page: j5790 year: 2018 ident: 10.4055/cios24500_ref29 publication-title: BMJ doi: 10.1136/bmj.j5790 – volume: 30 start-page: 1990 issue: 9 year: 2021 ident: 10.4055/cios24500_ref11 publication-title: J Shoulder Elbow Surg doi: 10.1016/j.jse.2021.05.018 – volume: 17 start-page: 346 issue: 4 year: 2014 ident: 10.4055/cios24500_ref20 publication-title: J Sci Med Sport doi: 10.1016/j.jsams.2013.07.008 – volume: 40 start-page: 2174 issue: 8 year: 2024 ident: 10.4055/cios24500_ref18 publication-title: Arthroscopy doi: 10.1016/j.arthro.2024.01.027 – volume: 27 start-page: 514 issue: 4 year: 2024 ident: 10.4055/cios24500_ref1 publication-title: Clin Shoulder Elb doi: 10.5397/cise.2024.00010 – volume: 38 start-page: 1086 issue: 4 year: 2022 ident: 10.4055/cios24500_ref8 publication-title: Arthroscopy doi: 10.1016/j.arthro.2022.01.040 – volume: 29 start-page: 1521 issue: 6 year: 2024 ident: 10.4055/cios24500_ref2 publication-title: J Orthop Sci doi: 10.1016/j.jos.2023.11.011 – volume: 86 start-page: 219 issue: 2 year: 2004 ident: 10.4055/cios24500_ref6 publication-title: J Bone Joint Surg Am doi: 10.2106/00004623-200402000-00002 – volume: 95 start-page: 2337 issue: 29 year: 2015 ident: 10.4055/cios24500_ref13 publication-title: Zhonghua Yi Xue Za Zhi – volume: 12 start-page: 1557 issue: 1 year: 2022 ident: 10.4055/cios24500_ref3 publication-title: Sci Rep doi: 10.1038/s41598-022-05608-x – volume: 15 start-page: 1467 issue: 6 year: 2016 ident: 10.4055/cios24500_ref19 publication-title: Biomech Model Mechanobiol doi: 10.1007/s10237-016-0776-3 – volume: 8 start-page: 351 issue: 4 year: 2021 ident: 10.4055/cios24500_ref16 publication-title: Temperature (Austin) doi: 10.1080/23328940.2021.1886392 – volume: 31 start-page: 2366 issue: 11 year: 2022 ident: 10.4055/cios24500_ref22 publication-title: J Shoulder Elbow Surg doi: 10.1016/j.jse.2022.05.004 |
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| Title | Acetaminophen Inhibits Fatty Infiltration without Impairing Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Repair |
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