TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells

Objective: Our objective was to investigate the mechanisms that govern natural killer (NK) cell responses to HIV, with a focus on specific receptor-ligand interactions involved in HIV recognition by NK cells. Design and Methods: We first performed a mass cytometry-based screen of NK cell receptor ex...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Vendrame, Elena, Seiler, Christof, Ranganath, Thanmayi, Zhao, Nancy Q, Vergara, Rosemary, Alary, Michel, Labbé, Annie Claude, Guédou, Fernand, Poudrier, Johanne, Holmes, Susan, Michel, Roger, Blish, Catherine A
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 10.09.2019 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	CD226 antigen CD4 antigen Cell recognition Cytometry HIV Human immunodeficiency virus Immunoglobulins Immunology Immunoreceptor tyrosine-based inhibition motif Ionomycin Lymphocytes T Natural killer cells NKG2 antigen Phenotypes adaptive NK cells HIV TIGIT mature
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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