Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay

When marked for degradation, surface receptor and transporter proteins are internalized and delivered to endosomes where they are packaged into intralumenal vesicles (ILVs). Many rounds of ILV formation create multivesicular bodies (MVBs) that fuse with lysosomes exposing ILVs to hydrolases for cata...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Mahmoud Abdul Karim, Samyn, Dieter Ronny, Mattie, Sevan, Christopher Leonard Brett
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.10.2017 Cold Spring Harbor Laboratory
Edition:	1.2
Subjects:	Cell Biology Cell fusion Endosomes Fusion protein Lysosomes SNAP receptors Rab7 vacuole ESCRT Rab-GTPase Pep12 SNARE membrane fusion Ypt7 Rab conversion syntaxin multivesicular body MVB endocytosis lysosome
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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