Antimicrobial peptides play a functional role in bumblebee anti-trypanosome defense

Bumblebees, amongst the most important of pollinators, are under enormous population pressures. One of these is disease. The bumblebee and its gut trypanosome Crithidia bombi are one of the fundamental models of ecological immunology. Although there is previous evidence of increased immune gene expr...

Full description

Saved in:
Bibliographic Details
Published in:bioRxiv
Main Authors: Soni Deshwal, Mallon, Eamonn
Format: Paper
Language:English
Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.10.2014
Cold Spring Harbor Laboratory
Edition:1.1
Subjects:
Antimicrobial peptides
Gene expression
Immunology
Intestinal microflora
Microbiota
Pollinators
RNA-mediated interference
RNAi
antimicrobial peptides
gut microbiota
ISSN:2692-8205, 2692-8205
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bumblebees, amongst the most important of pollinators, are under enormous population pressures. One of these is disease. The bumblebee and its gut trypanosome Crithidia bombi are one of the fundamental models of ecological immunology. Although there is previous evidence of increased immune gene expression upon Crithidia infection, recent work has focussed on the bumblebee's gut microbiota. Here, by knocking down gene expression using RNAi, we show for the first time that antimicrobial peptides (AMPs) have a functional role in anti-Crithidia defense.
Bibliography:SourceType-Working Papers-1
ObjectType-Working Paper/Pre-Print-1
content type line 50
ISSN:2692-8205
2692-8205
DOI:10.1101/010413