Antimicrobial peptides play a functional role in bumblebee anti-trypanosome defense

Bumblebees, amongst the most important of pollinators, are under enormous population pressures. One of these is disease. The bumblebee and its gut trypanosome Crithidia bombi are one of the fundamental models of ecological immunology. Although there is previous evidence of increased immune gene expr...

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Vydáno v:bioRxiv
Hlavní autoři: Soni Deshwal, Mallon, Eamonn
Médium: Paper
Jazyk:angličtina
Vydáno: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.10.2014
Cold Spring Harbor Laboratory
Vydání:1.1
Témata:
Antimicrobial peptides
Gene expression
Immunology
Intestinal microflora
Microbiota
Pollinators
RNA-mediated interference
RNAi
antimicrobial peptides
gut microbiota
ISSN:2692-8205, 2692-8205
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Popis
Shrnutí:Bumblebees, amongst the most important of pollinators, are under enormous population pressures. One of these is disease. The bumblebee and its gut trypanosome Crithidia bombi are one of the fundamental models of ecological immunology. Although there is previous evidence of increased immune gene expression upon Crithidia infection, recent work has focussed on the bumblebee's gut microbiota. Here, by knocking down gene expression using RNAi, we show for the first time that antimicrobial peptides (AMPs) have a functional role in anti-Crithidia defense.
Bibliografie:SourceType-Working Papers-1
ObjectType-Working Paper/Pre-Print-1
content type line 50
ISSN:2692-8205
2692-8205
DOI:10.1101/010413