Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection

Objective(s): To develop and evaluate the activity of bispecific antibodies (bsAbs) to enhance NK cell antibody-dependent cellular cytotoxicity (ADCC) against HIV-infected cells. Design: These bsAbs are based on patient-derived antibodies targeting the conserved gp41 stump of HIV Env, and also incor...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Ramadoss, Nitya S, Zhao, Nancy Q, Richardson, Barbra A, Grant, Philip M, Kim, Peter S, Blish, Catherine A
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 08.09.2019 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Affinity Avidity Bispecific antibodies Calcein CD16 antigen CD4 antigen Cell culture Cytotoxicity Degranulation Flow cytometry Glycoprotein gp41 HIV Human immunodeficiency virus Immunoglobulins Immunology Lymphocytes T Monoclonal antibodies Natural killer cells bispecific antibody NK cells HIV ADCC gp41
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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