Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

Differentiation of antigen-activated B cells into pro-proliferative germinal center (GC) B cells depends on the activity of the transcription factor MYC and the epigenetic writers DOT1L and EZH2. GCB-like Diffuse Large B Cell Lymphomas (GCB-DLBCLs) arise from GC B cells and closely resemble their ce...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Göbel, Camiel, Niccolai, Rachele, de Groot, Marnix H.P., Jayachandran, Jayashree, Traets, Joleen, Morris, Ben, Song, Ji-Ying, Azarang, Leyla, Kasa, Eirini, de Groot, Daniel, Kreft, Maaike, Kersten, Marie José, Aslam, Muhammad A., van Leeuwen, Fred, Jacobs, Heinz
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Laboratory 08.06.2024
Edition:	1.1
Subjects:	Cancer Biology
ISSN:	2692-8205
Online Access:	Get full text
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