Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and invasion. The closely related polysaccharide hepari...

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Veröffentlicht in:	bioRxiv
Hauptverfasser:	Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Guimond, Scott E., Miller, Gavin, Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.
Format:	Paper
Sprache:	Englisch
Veröffentlicht:	Cold Spring Harbor Laboratory 08.05.2020
Ausgabe:	1.2
Schlagworte:	Biochemistry heparin COVID-19 Spike SARS-CoV-2 viral inhibition, circular dichroism surface plasmon resonance molecular modelling coronavirus S1, RBD nCoV-19
ISSN:	2692-8205
Online-Zugang:	Volltext
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