Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water

BackgroundMunicipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013.ObjectiveTo determine the...

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Vydáno v:	Occupational and environmental medicine (London, England) Ročník 75; číslo 1; s. 46 - 51
Hlavní autoři:	Li, Ying, Fletcher, Tony, Mucs, Daniel, Scott, Kristin, Lindh, Christian H, Tallving, Pia, Jakobsson, Kristina
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England BMJ Publishing Group Ltd 01.01.2018 BMJ BMJ Publishing Group LTD BMJ Publishing Group
Edice:	Original Article
Témata:	Acids Arbetsmedicin och miljömedicin Blood & organ donations Drinking water elimination Environmental & Occupational Health Exposure Assessment Fire fighting Folkhälsovetenskap, global hälsa och socialmedicin Groundwater Half-life Health Sciences Households Hälsovetenskap life Medical and Health Sciences Medicin och hälsovetenskap Occupational Health and Environmental Health ORIGINAL ARTICLE Perfluoro compounds perfluoroalkyl acids Perfluorohexane pfhxs pfoa pfos Population Public Public Health, Global Health and Social Medicine serum concentrations Sulfonates Toxicology Urine Water pollution Sweden pfoa half-life pfos pfhxs
ISSN:	1351-0711, 1470-7926, 1470-7926
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Shrnutí:	BackgroundMunicipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013.ObjectiveTo determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives.MethodsUp to seven blood samples were collected between June 2014 and September 2016 from 106 participants (age 4–84 years, 53% female).ResultsMedian initial serum concentrations were PFHxS, 277 ng/mL (range 12–1660); PFOS, 345 ng/mL (range 24–1500); and PFOA, 18 ng/mL (range 2.4–92). The covariate-adjusted average rates of decrease in serum were PFHxS, 13% per year (95% CI 12% to 15%); PFOS, 20% per year (95% CI 19% to 22%); and PFOA, 26% per year (95% CI 24% to 28%). The observed data are consistent with a first-order elimination model. The mean estimated half-life was 5.3 years (95% CI 4.6 to 6.0) for PFHxS, 3.4 years (95% CI 3.1 to 3.7) for PFOS and 2.7 years (95% CI 2.5 to 2.9) for PFOA. The interindividual variation of half-life was around threefold when comparing the 5th and 95th percentiles. There was a marked sex difference with more rapid elimination in women for PFHxS and PFOS, but only marginally for PFOA.ConclusionsThe estimated half-life for PFHxS was considerably longer than for PFOS and PFOA. For PFHxS and PFOS, the average half-life is shorter than the previously published estimates. For PFOA the half-life is in line with the range of published estimates.
Bibliografie:	Original Article ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1351-0711 1470-7926 1470-7926
DOI:	10.1136/oemed-2017-104651