A New VISTA on combination therapy for negative checkpoint regulator blockade

Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, c...

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Veröffentlicht in:	Journal for immunotherapy of cancer Jg. 4; H. 1; S. 86
Hauptverfasser:	Deng, Jie, Le Mercier, Isabelle, Kuta, Anna, Noelle, Randolph J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BMJ Publishing Group Ltd 20.12.2016 BioMed Central BioMed Central Ltd BMJ Publishing Group LTD BMJ Publishing Group
Schlagworte:	Antigens Apoptosis Cancer Cancer therapies Combination drug therapy Combination immunotherapy Drugs Enzyme inhibitors FDA approval Immune response Immunology Immunotherapy Ligands Lung cancer Lymphocytes Medicine Medicine & Public Health Melanoma Methods Monoclonal antibodies Negative checkpoint regulators Observations Oncology Patient outcomes Phosphatase Review Reviews T cell receptors Tumors VISTA Negative checkpoint regulators Combination immunotherapy VISTA
ISSN:	2051-1426, 2051-1426
Online-Zugang:	Volltext
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