A New VISTA on combination therapy for negative checkpoint regulator blockade

Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, c...

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Podrobná bibliografie
Vydáno v:	Journal for immunotherapy of cancer Ročník 4; číslo 1; s. 86
Hlavní autoři:	Deng, Jie, Le Mercier, Isabelle, Kuta, Anna, Noelle, Randolph J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BMJ Publishing Group Ltd 20.12.2016 BioMed Central BioMed Central Ltd BMJ Publishing Group LTD BMJ Publishing Group
Témata:	Antigens Apoptosis Cancer Cancer therapies Combination drug therapy Combination immunotherapy Drugs Enzyme inhibitors FDA approval Immune response Immunology Immunotherapy Ligands Lung cancer Lymphocytes Medicine Medicine & Public Health Melanoma Methods Monoclonal antibodies Negative checkpoint regulators Observations Oncology Patient outcomes Phosphatase Review Reviews T cell receptors Tumors VISTA Negative checkpoint regulators Combination immunotherapy VISTA
ISSN:	2051-1426, 2051-1426
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, clinical trials demonstrating the efficacy of blocking antibodies against these molecules have invigorated the field of immunotherapy. In this review, we discuss the current understanding on established NCR blockade and how strategic combination therapy with anti-VISTA antibody can be used to target multiple non-redundant NCR pathways.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2051-1426 2051-1426
DOI:	10.1186/s40425-016-0190-5