A New VISTA on combination therapy for negative checkpoint regulator blockade

Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, c...

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Veröffentlicht in:Journal for immunotherapy of cancer Jg. 4; H. 1; S. 86
Hauptverfasser: Deng, Jie, Le Mercier, Isabelle, Kuta, Anna, Noelle, Randolph J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BMJ Publishing Group Ltd 20.12.2016
BioMed Central
BioMed Central Ltd
BMJ Publishing Group LTD
BMJ Publishing Group
Schlagworte:
Antigens
Apoptosis
Cancer
Cancer therapies
Combination drug therapy
Combination immunotherapy
Drugs
Enzyme inhibitors
FDA approval
Immune response
Immunology
Immunotherapy
Ligands
Lung cancer
Lymphocytes
Medicine
Medicine & Public Health
Melanoma
Methods
Monoclonal antibodies
Negative checkpoint regulators
Observations
Oncology
Patient outcomes
Phosphatase
Review
Reviews
T cell receptors
Tumors
VISTA
Negative checkpoint regulators
Combination immunotherapy
VISTA
ISSN:2051-1426, 2051-1426
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, clinical trials demonstrating the efficacy of blocking antibodies against these molecules have invigorated the field of immunotherapy. In this review, we discuss the current understanding on established NCR blockade and how strategic combination therapy with anti-VISTA antibody can be used to target multiple non-redundant NCR pathways.
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ISSN:2051-1426
2051-1426
DOI:10.1186/s40425-016-0190-5