E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT

Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that is relevant to LS pa...

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Veröffentlicht in:	Nature communications
Hauptverfasser:	Michela, Di Michele, Aurore, Attina, Pierre-François, Roux, Imène, Tabet, Sophie, Laguesse, Javier, Florido, Morane, Houdeville, Armelle, Choquet, Betty, Encislai, Giuseppe, Arena, Carlo, De Blasio, Olivia, Wendling, Francois-Xavier, Frenois, Laura, Papon, Lucille, Stuani, Maryse, Fuentes, Céline, Jahanault-Tagliani, Mélanie, Rousseau, Justine, Guégan, Yoan, Buscail, Pierrick, Dupré, Henri-Alexandre, Michaud, Geneviève, Rodier, Floriant, Bellvert, Hanna, Kulyk, Carole, Ferraro Peyret, Hugo, Mathieu, Pierre, Close, Francesca, Rapino, Cédric, Chaveroux, Nelly, Pirot, Lucie, Rubio, Adeline, Torro, Tania, Sorg, Fabrice, Ango, Christophe, Hirtz, Vincent, Compan, Elise, Lebigot, Andrea, Legati, Daniele, Ghezzi, Laurent, Nguyen, Alexandre, David, Claude, Sardet, Matthieu, Lacroix, Laurent, Le Cam
Format:	Paper Journal Article
Sprache:	Englisch
Veröffentlicht:	Cold Spring Harbor Laboratory 02.10.2024 Nature Publishing Group
Ausgabe:	1.2
Schlagworte:	Biochemistry, Molecular Biology Developmental Biology Life Sciences pyruvate metabolism translation Leigh syndrome E4F1 Elongator complex integrated stress response
ISSN:	2041-1723, 2692-8205, 2041-1723
Online-Zugang:	Volltext
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