E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT

Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that is relevant to LS pa...

Celý popis

Podrobná bibliografia

Vydané v:	Nature communications
Hlavní autori:	Michela, Di Michele, Aurore, Attina, Pierre-François, Roux, Imène, Tabet, Sophie, Laguesse, Javier, Florido, Morane, Houdeville, Armelle, Choquet, Betty, Encislai, Giuseppe, Arena, Carlo, De Blasio, Olivia, Wendling, Francois-Xavier, Frenois, Laura, Papon, Lucille, Stuani, Maryse, Fuentes, Céline, Jahanault-Tagliani, Mélanie, Rousseau, Justine, Guégan, Yoan, Buscail, Pierrick, Dupré, Henri-Alexandre, Michaud, Geneviève, Rodier, Floriant, Bellvert, Hanna, Kulyk, Carole, Ferraro Peyret, Hugo, Mathieu, Pierre, Close, Francesca, Rapino, Cédric, Chaveroux, Nelly, Pirot, Lucie, Rubio, Adeline, Torro, Tania, Sorg, Fabrice, Ango, Christophe, Hirtz, Vincent, Compan, Elise, Lebigot, Andrea, Legati, Daniele, Ghezzi, Laurent, Nguyen, Alexandre, David, Claude, Sardet, Matthieu, Lacroix, Laurent, Le Cam
Médium:	Paper Journal Article
Jazyk:	English
Vydavateľské údaje:	Cold Spring Harbor Laboratory 02.10.2024 Nature Publishing Group
Vydanie:	1.2
Predmet:	Biochemistry, Molecular Biology Developmental Biology Life Sciences pyruvate metabolism translation Leigh syndrome E4F1 Elongator complex integrated stress response
ISSN:	2041-1723, 2692-8205, 2041-1723
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!