Ambulatory ECG and analysis of heart rate variability in Parkinson's disease

OBJECTIVES Cardiovascular reflex tests have shown both sympathetic and parasympathetic failure in Parkinson's disease. These tests, however, describe the autonomic responses during a restricted time period and have great individual variability, providing a limited view of the autonomic cardiac...

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Vydáno v:Journal of neurology, neurosurgery and psychiatry Ročník 70; číslo 3; s. 305 - 310
Hlavní autoři: Haapaniemi, T H, Pursiainen, V, Korpelainen, J T, Huikuri, H V, Sotaniemi, K A, Myllylä, V V
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BMJ Publishing Group Ltd 01.03.2001
BMJ
BMJ Publishing Group LTD
BMJ Group
Témata:
Abnormalities
Aged
Analysis
autonomic nervous system
Biological and medical sciences
Circadian Rhythm - physiology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnosis
Electrocardiogram
Electrocardiography
Female
heart rate
Heart Rate - physiology
Humans
Male
Medical sciences
Middle Aged
Nervous system, Autonomic
Neurology
Parkinson Disease - physiopathology
Parkinson's disease
United Kingdom
Human
Nervous system diseases
Pathophysiology
Parkinson disease
Electroencephalography
Cerebral disorder
Heart rate
Electrodiagnosis
Autonomic nervous system
Central nervous system disease
Degenerative disease
Ambulatory
Extrapyramidal syndrome
ISSN:0022-3050, 1468-330X
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Shrnutí:OBJECTIVES Cardiovascular reflex tests have shown both sympathetic and parasympathetic failure in Parkinson's disease. These tests, however, describe the autonomic responses during a restricted time period and have great individual variability, providing a limited view of the autonomic cardiac control mechanisms. Thus, they do not reflect tonic autonomic regulation. The aim was to examine tonic autonomic cardiovascular regulation in untreated patients with Parkinson's disease. METHODS 24 Hour ambulatory ECG was recorded in 54 untreated patients with Parkinson's disease and 47 age matched healthy subjects. In addition to the traditional spectral (very low frequency, VLF; low frequency, LF; high frequency, HF) and non-spectral components of heart rate variability, instantaneous beat to beat variability (SD1) and long term continuous variability (SD2) derived from Poincaré plots, and the slope of the power law relation were analysed. RESULTS All spectral components (p<0.01) and the slope of the power-law relation (p<0.01) were lower in the patients with Parkinson's disease than in the control subjects. The Unified Parkinson's disease rating scale total and motor scores had a negative correlation with VLF and LF power spectrum values and the power law relation slopes. Patients with mild hypokinesia had higher HF values than patients with more severe hypokinesia. Tremor and rigidity were not associated with the HR variability parameters. CONCLUSIONS Parkinson's disease causes dysfunction of the diurnal autonomic cardiovascular regulation as demonstrated by the spectral measures of heart rate variability and the slope of the power law relation. This dysfunction seems to be more profound in patients with more severe Parkinson's disease.
Bibliografie:ark:/67375/NVC-16X9JH9K-D
local:jnnp;70/3/305
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PMID:11181850
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ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.70.3.305