Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis

Background: The severity of lung disease varies widely in patients with cystic fibrosis (CF) who have the same type of mutations of the cystic fibrosis transmembrane regulator (CFTR) gene, suggesting involvement of “modifier” genes. The nitric oxide synthase 1 (NOS1) gene is a candidate for this rol...

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Bibliographic Details
Published in:	Thorax Vol. 59; no. 2; pp. 156 - 158
Main Authors:	Texereau, J, Marullo, S, Hubert, D, Coste, J, Dusser, D J, Dall’Ava-Santucci, J, Dinh-Xuan, A T
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd and British Thoracic Society 01.02.2004 BMJ BMJ Publishing Group Ltd BMJ Publishing Group LTD BMJ Group
Subjects:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body mass index Cardiology. Vascular system Cystic Fibrosis Cystic Fibrosis - enzymology Cystic Fibrosis - genetics Cystic Fibrosis - physiopathology Dinucleotide Repeats - genetics Female Forced Expiratory Volume - genetics Gastroenterology. Liver. Pancreas. Abdomen Genes genetics Genotype & phenotype Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Lung diseases lung function Male Medical sciences Mutation Nitric oxide Nitric Oxide - analysis Nitric Oxide Synthase - genetics nitric oxide synthase 1 (NOS1) gene Nitric Oxide Synthase Type I Other diseases. Semiology Pneumology polymorphism Polymorphism, Genetic - genetics Human Respiratory disease Enzyme Metabolic diseases Cystic fibrosis Potential Nitric-oxide synthase Genetic disease Lung function Gene Digestive diseases Anesthesia Oxidoreductases Circulatory system Cardiology Pancreatic disease
ISSN:	0040-6376, 1468-3296
Online Access:	Get full text
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