Association between gene expression signatures and clinical outcomes of pembrolizumab versus paclitaxel in advanced gastric cancer: exploratory analysis from the randomized, controlled, phase III KEYNOTE-061 trial

BackgroundIn the randomized, controlled, phase III KEYNOTE-061 trial, second-line pembrolizumab did not significantly prolong overall survival (OS) versus paclitaxel in patients with PD-L1-positive (combined positive score ≥1) advanced gastric/gastroesophageal junction (G/GEJ) cancer but did elicit...

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Bibliographic Details
Published in:	Journal for ImmunoTherapy of Cancer Vol. 11; no. 6; p. e006920
Main Authors:	Shitara, Kohei, Di Bartolomeo, Maria, Mandala, Mario, Ryu, Min-Hee, Caglevic, Christian, Olesinski, Tomasz, Chung, Hyun Cheol, Muro, Kei, Goekkurt, Eray, McDermott, Raymond S, Mansoor, Wasat, Wainberg, Zev A, Shih, Chie-Schin, Kobie, Julie, Nebozhyn, Michael, Cristescu, Razvan, Cao, Z Alexander, Loboda, Andrey, Özgüroğlu, Mustafa
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 01.06.2023 BMJ BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original research
Subjects:	Angiogenesis Antibodies Antibodies, Monoclonal, Humanized Antibodies, Monoclonal, Humanized - therapeutic use Cancer Cancer therapies Cell death Clinical outcomes Clinical/Translational Cancer Immunotherapy Gastric cancer Gastrointestinal Neoplasms Gene expression Gene Expression Profiling Genetic Markers Growth factors Humanized Humans Hypoxia Immunotherapy Medical prognosis Metastasis Monoclonal Monoclonal antibodies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Patients Programmed Cell Death 1 Receptor RC254-282 Response rates Review boards Stomach Neoplasms Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Targeted cancer therapy Transcriptome Tumors United States > US Programmed Cell Death 1 Receptor Gene Expression Profiling Gastrointestinal Neoplasms Genetic Markers Immunotherapy
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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