Cartilage markers in synovial fluid in symptomatic knee osteoarthritis

OBJECTIVE To investigate if the relative content of aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid lavage samples differs between individuals with knee pain with or without evidence of radiological knee osteoarthritis (joint space narrowing). METHODS In a community based c...

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Podrobná bibliografie
Vydáno v:	Annals of the rheumatic diseases Ročník 56; číslo 1; s. 64 - 67
Hlavní autoři:	Petersson, Ingemar F, Sandqvist, Lars, Svensson, Björn, Saxne, Tore
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BMJ Publishing Group Ltd and European League Against Rheumatism 01.01.1997 BMJ Elsevier Limited
Témata:	Adult Aggrecans Biological and medical sciences Biomarkers - analysis Body mass index cartilage markers Cartilage Oligomeric Matrix Protein Chondroitin Sulfate Proteoglycans - analysis Clinical Medicine Cohort Studies Concise Reports Disease Diseases of the osteoarticular system Extracellular Matrix Proteins - analysis Female Fluids Glycoproteins - analysis Hospitals Humans Klinisk medicin Knee Knee Joint - diagnostic imaging knee joint lavage Lectins, C-Type Male Matrilin Proteins Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Middle Aged Orthopaedics Ortopedi Osteoarthritis Osteoarthritis - diagnostic imaging Osteoarthritis - metabolism Pain - metabolism Proteins Proteoglycans - analysis Radiography Ratios Rheumatoid arthritis Studies synovial fluid Synovial Fluid - chemistry Knee Human Diseases of the osteoarticular system Biological marker Lower limb Exploration Washing Cartilage Synovial fluid Symptomatology Turnover Arthropathy Degenerative disease Diagnosis Technique Osteoarthritis
ISSN:	0003-4967, 1468-2060
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Popis
Shrnutí:	OBJECTIVE To investigate if the relative content of aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid lavage samples differs between individuals with knee pain with or without evidence of radiological knee osteoarthritis (joint space narrowing). METHODS In a community based cohort of 204 individuals aged 35-54 years with chronic (>3 months duration) knee pain, a subgroup of 45 subjects with radiographic osteoarthritis, grade I according to the Ahlbäck classification, was randomly chosen; 45 individuals, age and sex matched from the same cohort with chronic knee pain but with normal radiographs, served as controls. Knee joint fluid was obtained by a standardised lavage procedure. The concentrations of aggrecan core protein epitopes and a cartilage matrix protein (COMP) were determined by immuno-assays and the aggrecan/COMP con-centration ratio was calculated. RESULTS The aggrecan/COMP ratio was higher (P < 0.001) in the group with radiographic osteoarthritis than in the control group. CONCLUSIONS The higher aggrecan/COMP ratios in osteoarthritis could reflect increased cartilage matrix turnover in osteoarthritis with predominant release of aggrecan fragments. Synovial fluid analysis of cartilage markers holds promise as a useful means of monitoring changes in the cartilage turnover in studies of pathogenic mechanisms in osteoarthritis.
Bibliografie:	local:annrheumdis;56/1/64 ark:/67375/NVC-19D14TV3-T href:annrheumdis-56-64.pdf PMID:9059144 istex:A329F0FDE481D94D36A36B26326B43DC56D1AFA3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.56.1.64