Cartilage markers in synovial fluid in symptomatic knee osteoarthritis

OBJECTIVE To investigate if the relative content of aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid lavage samples differs between individuals with knee pain with or without evidence of radiological knee osteoarthritis (joint space narrowing). METHODS In a community based c...

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Bibliographic Details
Published in:Annals of the rheumatic diseases Vol. 56; no. 1; pp. 64 - 67
Main Authors: Petersson, Ingemar F, Sandqvist, Lars, Svensson, Björn, Saxne, Tore
Format: Journal Article
Language:English
Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.01.1997
BMJ
Elsevier Limited
Subjects:
Adult
Aggrecans
Biological and medical sciences
Biomarkers - analysis
Body mass index
cartilage markers
Cartilage Oligomeric Matrix Protein
Chondroitin Sulfate Proteoglycans - analysis
Clinical Medicine
Cohort Studies
Concise Reports
Disease
Diseases of the osteoarticular system
Extracellular Matrix Proteins - analysis
Female
Fluids
Glycoproteins - analysis
Hospitals
Humans
Klinisk medicin
Knee
Knee Joint - diagnostic imaging
knee joint lavage
Lectins, C-Type
Male
Matrilin Proteins
Medical and Health Sciences
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Orthopaedics
Ortopedi
Osteoarthritis
Osteoarthritis - diagnostic imaging
Osteoarthritis - metabolism
Pain - metabolism
Proteins
Proteoglycans - analysis
Radiography
Ratios
Rheumatoid arthritis
Studies
synovial fluid
Synovial Fluid - chemistry
Knee
Human
Diseases of the osteoarticular system
Biological marker
Lower limb
Exploration
Washing
Cartilage
Synovial fluid
Symptomatology
Turnover
Arthropathy
Degenerative disease
Diagnosis
Technique
Osteoarthritis
ISSN:0003-4967, 1468-2060
Online Access:Get full text
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Summary:OBJECTIVE To investigate if the relative content of aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid lavage samples differs between individuals with knee pain with or without evidence of radiological knee osteoarthritis (joint space narrowing). METHODS In a community based cohort of 204 individuals aged 35-54 years with chronic (>3 months duration) knee pain, a subgroup of 45 subjects with radiographic osteoarthritis, grade I according to the Ahlbäck classification, was randomly chosen; 45 individuals, age and sex matched from the same cohort with chronic knee pain but with normal radiographs, served as controls. Knee joint fluid was obtained by a standardised lavage procedure. The concentrations of aggrecan core protein epitopes and a cartilage matrix protein (COMP) were determined by immuno-assays and the aggrecan/COMP con-centration ratio was calculated. RESULTS The aggrecan/COMP ratio was higher (P < 0.001) in the group with radiographic osteoarthritis than in the control group. CONCLUSIONS The higher aggrecan/COMP ratios in osteoarthritis could reflect increased cartilage matrix turnover in osteoarthritis with predominant release of aggrecan fragments. Synovial fluid analysis of cartilage markers holds promise as a useful means of monitoring changes in the cartilage turnover in studies of pathogenic mechanisms in osteoarthritis.
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PMID:9059144
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ISSN:0003-4967
1468-2060
DOI:10.1136/ard.56.1.64