Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19

Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects o...

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Published in:bioRxiv
Main Authors: Wilk, Aaron J, Rustagi, Arjun, Zhao, Nancy Q, Martin, Beth A, Rogers, Angela J, Blish, Catherine A
Format: Paper
Language:English
Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.10.2020
Cold Spring Harbor Laboratory
Edition:1.1
Subjects:
Coronaviruses
COVID-19
Immune response
Immunology
Leukocytes (neutrophilic)
ISSN:2692-8205, 2692-8205
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Abstract Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects of their criticism of our analysis to be problematic. Here we respond briefly to misunderstandings and inaccuracies in their commentary that may have led to misinformed interpretation of our results. Competing Interest Statement The authors have declared no competing interest.
AbstractList We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects of their criticism of our analysis to be problematic. Here we respond briefly to misunderstandings and inaccuracies in their commentary that may have led to misinformed interpretation of our results.
Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects of their criticism of our analysis to be problematic. Here we respond briefly to misunderstandings and inaccuracies in their commentary that may have led to misinformed interpretation of our results. Competing Interest Statement The authors have declared no competing interest.
Author Martin, Beth A
Blish, Catherine A
Wilk, Aaron J
Rustagi, Arjun
Zhao, Nancy Q
Rogers, Angela J
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Cites_doi 10.1101/2020.09.27.312538
10.1002/jha2.44
10.1038/s41587-020-0591-3
10.4269/ajtmh.20-0721
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2020, Posted by Cold Spring Harbor Laboratory
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Snippet Abstract We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe...
We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We...
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SubjectTerms Coronaviruses
COVID-19
Immune response
Immunology
Leukocytes (neutrophilic)
Title Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19
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