Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)

Serious flaws in the scientific evaluation in the RAR incorrectly characterise the potential for a carcinogenic hazard from exposure to glyphosate. Since the RAR is the basis for the European Food Safety Agency (EFSA) conclusion, 4 it is critical that these shortcomings are corrected. [...]the WG al...

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Published in:	Journal of Epidemiology and Community Health Vol. 70; no. 8; pp. 741 - 745
Main Authors:	Portier, Christopher J, Armstrong, Bruce K, Baguley, Bruce C, Baur, Xaver, Belyaev, Igor, Bellé, Robert, Belpoggi, Fiorella, Biggeri, Annibale, Bosland, Maarten C, Bruzzi, Paolo, Budnik, Lygia Therese, Bugge, Merete D, Burns, Kathleen, Calaf, Gloria M, Carpenter, David O, Carpenter, Hillary M, López-Carrillo, Lizbeth, Clapp, Richard, Cocco, Pierluigi, Consonni, Dario, Comba, Pietro, Craft, Elena, Dalvie, Mohamed Aqiel, Davis, Devra, Demers, Paul A, De Roos, Anneclaire J, DeWitt, Jamie, Forastiere, Francesco, Freedman, Jonathan H, Fritschi, Lin, Gaus, Caroline, Gohlke, Julia M, Goldberg, Marcel, Greiser, Eberhard, Hansen, Johnni, Hardell, Lennart, Hauptmann, Michael, Huang, Wei, Huff, James, James, Margaret O, Jameson, C W, Kortenkamp, Andreas, Kopp-Schneider, Annette, Kromhout, Hans, Larramendy, Marcelo L, Landrigan, Philip J, Lash, Lawrence H, Leszczynski, Dariusz, Lynch, Charles F, Magnani, Corrado, Mandrioli, Daniele, Martin, Francis L, Merler, Enzo, Michelozzi, Paola, Miligi, Lucia, Miller, Anthony B, Mirabelli, Dario, Mirer, Franklin E, Naidoo, Saloshni, Perry, Melissa J, Petronio, Maria Grazia, Pirastu, Roberta, Portier, Ralph J, Ramos, Kenneth S, Robertson, Larry W, Rodriguez, Theresa, Röösli, Martin, Ross, Matt K, Roy, Deodutta, Rusyn, Ivan, Saldiva, Paulo, Sass, Jennifer, Savolainen, Kai, Scheepers, Paul T J, Sergi, Consolato, Silbergeld, Ellen K, Smith, Martyn T, Stewart, Bernard W, Sutton, Patrice, Tateo, Fabio, Terracini, Benedetto, Thielmann, Heinz W, Thomas, David B, Vainio, Harri, Vena, John E, Vineis, Paolo, Weiderpass, Elisabete, Weisenburger, Dennis D, Woodruff, Tracey J, Yorifuji, Takashi, Yu, Il Je, Zambon, Paola, Zeeb, Hajo, Zhou, Shu-Feng
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 01.08.2016 BMJ BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	1117 Public Health And Health Services 1604 Human Geography 2713 Epidemiology 2739 Public Health B290 CANCER CANCER; ENVIRONMENTAL HEALTH; Environmental epidemiology; PUBLIC HEALTH POLICY; TOXICOLOGY; Epidemiology; Public Health, Environmental and Occupational Health Carcinogen Carcinogenic evaluation Carcinogenic hazard Carcinogenicity Carcinogens Carcinogens - toxicity Clinical nursing research Commentaries Commentary Consumer Product Safety Control data Environmental and Occupational Health Environmental epidemiology ENVIRONMENTAL HEALTH Epidemiology European Food Safety Agency (EFSA) European Food Safety Authority European Union Food Safety Genetic research Glycine Glycine - analogs & derivatives Glycine - toxicity Glyphosate Health risk assessment Herbicide Herbicides Herbicides - toxicity Humans Insecticide Interdisciplinary research International Agencies International Agency for Research on Cancer International Agency for Research on Cancer (IARC) Medical research Neoplasms Neoplasms - chemically induced Non Hodgkin lymphoma Pesticides Public Health PUBLIC HEALTH POLICY Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences Research facilities Rodents Studies Thyroid TOXICOLOGY Environmental epidemiology TOXICOLOGY CANCER ENVIRONMENTAL HEALTH PUBLIC HEALTH POLICY
ISSN:	0143-005X, 1470-2738, 1470-2738
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Summary:	Serious flaws in the scientific evaluation in the RAR incorrectly characterise the potential for a carcinogenic hazard from exposure to glyphosate. Since the RAR is the basis for the European Food Safety Agency (EFSA) conclusion, 4 it is critical that these shortcomings are corrected. [...]the WG also saw a significant increase in the incidence of pancreatic islet cell adenomas in two studies in male Sprague-Dawley rats. 14-16 In one of these rat studies, thyroid gland adenomas in females and liver adenomas in males were also increased.
Bibliography:	SourceType-Scholarly Journals-1 ObjectType-Commentary-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0143-005X 1470-2738 1470-2738
DOI:	10.1136/jech-2015-207005