Airflow obstruction and small airway dysfunction following pulmonary tuberculosis: a cross-sectional survey

ObjectivesPulmonary function impairment and chronic respiratory symptoms after tuberculosis are relatively common in low-income and middle-income countries. We aimed to estimate the impact of post-tuberculosis (post-TB) on pulmonary function.MethodsThis large cross-sectional, population-based study...

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Veröffentlicht in:Thorax Jg. 78; H. 3; S. 274 - 280
Hauptverfasser: Xing, Zhenzhen, Sun, Tieying, Janssens, Jean-Paul, Chai, Di, Liu, Weiming, Tong, Yaqi, Wang, Yuxia, Ma, Yali, Pan, Mingming, Cui, Jia, Wang, Chen, Guo, YanFei
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England BMJ Publishing Group Ltd and British Thoracic Society 01.03.2023
BMJ
BMJ Publishing Group LTD
BMJ Publishing Group
Schriftenreihe:Original research
Schlagworte:
Adult
Age
Airway Obstruction
Airway Obstruction - epidemiology
Airway Obstruction - etiology
Asthma
Chronic obstructive pulmonary disease
COPD epidemiology
Cross-Sectional Studies
Forced Expiratory Volume
Humans
info:eu-repo/classification/ddc/616
Low income groups
Lung
Oxygen saturation
Population
Pulmonary Disease, Chronic Obstructive
Questionnaires
Respiratory infection
Risk Factors
Self report
Spirometry
Tuberculosis
Tuberculosis, Pulmonary
Tuberculosis, Pulmonary - epidemiology
Variance analysis
Vital Capacity
Beijing China
China
COPD epidemiology
respiratory infection
tuberculosis
ISSN:0040-6376, 1468-3296, 1468-3296
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Zusammenfassung:ObjectivesPulmonary function impairment and chronic respiratory symptoms after tuberculosis are relatively common in low-income and middle-income countries. We aimed to estimate the impact of post-tuberculosis (post-TB) on pulmonary function.MethodsThis large cross-sectional, population-based study included subjects aged 15 years or older with technically acceptable postbronchodilator spirometry measurements. Post-TB was diagnosed on the basis of radiological evidence and/or medical history. Airflow obstruction was defined as a postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratio below the lower limit of normal of Global Lung Function Initiative (GLI) lung function equations. Small airway dysfunction was diagnosed if at least two of the following indicators were less than 65% of predicted: maximal mid-expiratory flow, forced expiratory flow (FEF) 50% or FEF 75%.ResultsIn this population sample (N=8680, mean age: 40.1 years), 610 (7.0% (95% CI 6.5 to 7.6) participants were post-TB. Post-TB subjects had more frequent respiratory symptoms (46.8% vs 28.3%). Among post-TB subjects, 130 (21.3% (95% CI 18.1 to 24.8)) had airflow obstruction; OR of airflow obstruction was significantly associated with post-TB after adjustment for other confounding factors (OR 1.31, 95% CI 1.05 to 1.62). Post-TB was also associated with small airway dysfunction (OR 1.28, 95% CI1.07 to 1.53), which was present in 297 (48.9% (95% CI 33.9 to 53.0)) post-TB subjects.ConclusionsOur findings support existing knowledge that post-TB is positively associated with pulmonary function impairment and make for frequent respiratory symptoms. Post-TB should be considered as a potentially important cause of airflow obstruction and respiratory symptoms in patients originating from countries with a high burden of tuberculosis.
Bibliographie:Original research
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0040-6376
1468-3296
1468-3296
DOI:10.1136/thoraxjnl-2021-218345