Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis

Objective: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable y...

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Bibliographic Details
Published in:Annals of the rheumatic diseases Vol. 66; no. 1; pp. 121 - 123
Main Authors: Rantapää-Dahlqvist, S, Boman, K, Tarkowski, A, Hallmans, G
Format: Journal Article
Language:English
Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.01.2007
BMJ
Elsevier Limited
BMJ Group
Subjects:
Adult
Aged
Arthritis
Arthritis, Rheumatoid - blood
Autoantibodies - blood
Biological and medical sciences
Biological Markers/blood
Biomarkers - blood
Blood Donors
C reactive protein
C-Reactive Protein - analysis
Case-Control Studies
CCP
Chemokine CCL2 - blood
Chi-Square Distribution
Citrulline - immunology
Concise Report
CRP
cyclic citrullinated peptide
Disease Progression
Diseases of the osteoarticular system
Female
high-sensitivity C reactive protein
hsCRP
Humans
IgM-RF
Immunoglobulin M - blood
immunoglobulin M-rheumatoid factor
Immunoglobulins
Inflammatory joint diseases
Male
MCP
Medical and Health Sciences
Medical sciences
Medicin och hälsovetenskap
Middle Aged
monocyte chemoattractant protein
Rheumatism
Rheumatoid arthritis
Rheumatoid Factor - blood
Rheumatoid/blood
secretory phospholipase
Severity of Illness Index
sPL
Time Factors
Up-Regulation
Sweden
Human
Immunopathology
Rheumatoid factor
Chronic
Immunoglobulins
Monocyte
Antibody
Rheumatoid arthritis
Diseases of the osteoarticular system
Autoimmune disease
Inflammatory joint disease
Citrulline
Rheumatoid/blood
Arthritis
ISSN:0003-4967, 1468-2060, 1468-2060
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Summary:Objective: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis. Methods: A nested case–control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay. Results: When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls. Conclusion: Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis.
Bibliography:Correspondence to:
 S Rantapää-Dahlqvist
 Department of Rheumatology, University Hospital, SE-901 85 Umeå, Sweden; Solbritt.Rantapaa.Dahlqvist@medicin.umu.se
PMID:16740681
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ISSN:0003-4967
1468-2060
1468-2060
DOI:10.1136/ard.2006.057331