White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging

Objective: To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI). Background: Although Alzheimer's disease pathology mainly affects cortical grey matter, previous pathological a...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry Jg. 72; H. 6; S. 742 - 746
Hauptverfasser:	Bozzali, M, Falini, A, Franceschi, M, Cercignani, M, Zuffi, M, Scotti, G, Comi, G, Filippi, M
Format:	Journal Article Tagungsbericht
Sprache:	Englisch
Veröffentlicht:	London BMJ Publishing Group Ltd 01.06.2002 BMJ BMJ Publishing Group LTD BMJ Group
Schlagworte:	Acquisitions & mergers Age Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - pathology Alzheimer's disease Anisotropy Attention deficit hyperactivity disorder Biological and medical sciences Brain Brain damage Cerebral Cortex - pathology Cognitive ability Corpus Callosum - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diffusion diffusion tensor magnetic resonance imaging DT-MRI Female fractional anisotropy Humans intervoxel coherence Magnetic resonance imaging Magnetic Resonance Imaging - methods Male mean diffusivity Medical sciences Middle Aged mini mental state examination MMSE Net losses Neurology NMR Nuclear magnetic resonance Pathology PGSE Physiological aspects pulsed gradient spin echo regions of interest ROIs Studies TSE turbo spin echo white matter damage Italy Human Nervous system diseases Pathophysiology Alzheimer disease Nuclear magnetic resonance imaging White matter Cerebral disorder Central nervous system disease Medical imagery Degenerative disease Diffusion Microstructure Tensor method Brain (vertebrata)
ISSN:	0022-3050, 1468-330X
Online-Zugang:	Volltext
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