Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis

OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity (D̄) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from pa...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry Vol. 70; no. 3; pp. 311 - 317
Main Authors: Cercignani, M, Bozzali, M, Iannucci, G, Comi, G, Filippi, M
Format: Journal Article
Language:English
Published: London BMJ Publishing Group Ltd 01.03.2001
BMJ
BMJ Publishing Group LTD
BMJ Group
Subjects:
Adult
Analysis
Biological and medical sciences
Brain - pathology
Brain chemistry
Development and progression
Female
grey matter diffusivity
Humans
Magnetic Resonance Imaging - methods
magnetisation transfer ratio
Male
Medical sciences
Middle Aged
Multiple sclerosis
Multiple Sclerosis - pathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Scanners
white matter diffusity
United Kingdom
Human
Nervous system diseases
Multiple sclerosis
Magnetization
Pathophysiology
Grey matter
Nuclear magnetic resonance imaging
White matter
Inflammatory disease
Central nervous system disease
Transfer
Medical imagery
Brain (vertebrata)
ISSN:0022-3050, 1468-330X
Online Access:Get full text
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Summary:OBJECTIVE To assess the feasibility of a new technique based on diffusion anisotropy to segment white and grey matter of the brain. To use this technique to measure the mean diffusivity (D̄) and magnetisation transfer ratio (MTR) of normal appearing white matter (NAWM) and grey matter (NAGM) from patients with multiple sclerosis. METHODS Dual echo turbo spin echo, MT, and diffusion weighted scans of the brain were obtained from 30 patients with multiple sclerosis and 18 sex and age matched healthy controls. After image coregistration and removal of T2 visible lesions, white and grey matter were segmented from 10 supratentorial slices using diffusion anisotropy thresholds. Histograms of the average MTR and D̄ were created for normal white and grey matter of controls and NAWM and NAGM of patients with multiple sclerosis. RESULTS All the MTR histogram derived metrics of the NAWM from patients with multiple sclerosis were significantly lower than those of white matter from controls. The peak height of the D̄histogram of NAWM from patients with multiple sclerosis was also significantly different from that of normal white matter. The average MTR, the peak location of the MTR histogram, and peak height of theD̄ histogram of the NAGM of patients with multiple sclerosis were significantly lower than the corresponding quantities of grey matter from controls. CONCLUSIONS A technique was developed for segmenting white and grey matter with the potential for improving the understanding of the pathophysiology of many neurological conditions. Its application to the study of multiple sclerosis confirms the presence of a diffuse tissue damage in the NAWM of these patients and suggests that subtle changes also occur in the NAGM.
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ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.70.3.311