Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway

BackgroundWe previously showed selectively hampered activation of lymph node-resident (LNR) dendritic cell (DC) subsets in the breast cancer (BrC) sentinel lymph node (SLN) to precede a state of profound T cell anergy. Reactivating these DC subsets by intratumoral delivery of the Toll-like receptor-...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 8; no. 2; p. e000761
Main Authors:	van Pul, Kim M, Vuylsteke, Ronald J C L M, de Beijer, Monique T A, van de Ven, Rieneke, van den Tol, M Petrousjka, Stockmann, Hein B A C, de Gruijl, Tanja D
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 01.10.2020 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original research
Subjects:	Basic Tumor Immunology Breast cancer breast neoplasms Cancer Chemotherapy Cytokines Cytotoxicity dendritic cells Flow cytometry immunomodulation Immunotherapy Lymphatic system Lymphocytes Melanoma Tumor necrosis factor-TNF United States > US immunomodulation breast neoplasms dendritic cells
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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