Estimated life expectancy of Parkinson’s patients compared with the UK population

Objective:To calculate the best possible estimates for age specific life expectancy (LE) and anticipated age at the time of death (AAD) in patients with Parkinson’s disease (PD) compared with the general population in the UK. These may be of greater value to patients than standardised mortality rati...

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Veröffentlicht in:Journal of neurology, neurosurgery and psychiatry Jg. 78; H. 12; S. 1304 - 1309
Hauptverfasser: Ishihara, Lianna S, Cheesbrough, Anne, Brayne, Carol, Schrag, Anette
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BMJ Publishing Group Ltd 01.12.2007
BMJ
BMJ Publishing Group LTD
BMJ Group
Schlagworte:
Adult
Age Distribution
Age groups
Age of Onset
Aged
Aged, 80 and over
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine Agonists - therapeutic use
Estimates
European studies
Female
Humans
Levodopa - therapeutic use
Life Expectancy
Male
Medical prognosis
Medical sciences
Middle Aged
Mortality
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Parkinson Disease - diagnosis
Parkinson Disease - drug therapy
Parkinson Disease - mortality
Parkinson's disease
Population
Predictive Value of Tests
Sex Distribution
United Kingdom - epidemiology
England
Italy
United Kingdom > UK
France
Wales
Human
Nervous system diseases
ISSN:0022-3050, 1468-330X, 1468-330X
Online-Zugang:Volltext
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Zusammenfassung:Objective:To calculate the best possible estimates for age specific life expectancy (LE) and anticipated age at the time of death (AAD) in patients with Parkinson’s disease (PD) compared with the general population in the UK. These may be of greater value to patients than standardised mortality ratios (SMRs), which are usually reported in studies on mortality in PD.Methods:A literature review identified articles with data on age stratified life expectancy or SMRs to calculate estimations of LE using the Gompertz function and data on mortality and LE in the UK from the Office of National Statistics and Actuarial Department for the year 2003.Results:Two UK studies and four from Western Europe were used to estimate LE and AAD for patients with PD from SMRs. The mean LEs of patients with PD compared with the general population were: 38 (SD 5) years for onset between 25 and 39 years compared with 49 (SD 5) years; 21 (SD 5) years for onset between 40 and 64 years compared with 31 (SD 7) years; and 5 (SD 4) years for onset age ⩾65 years compared with 9 (SD 5) years. The average AAD of patients with PD with onset between 25 and 39 years was 71 (SD 3) years and considerably lower than that of the general population (82 (SD 2) years). The difference between average AAD for older individuals with PD (onset ⩾65 years) and the general population was smaller, with an AAD of approximately 88 (SD 7) years compared with 91 (SD 5) years.Conclusions:The calculations showed that LE and AAD in PD are reduced for all onset ages but this reduction is greatest in individuals with a young onset. While the results are average estimates, these can provide useful indications of LE and AAD.
Bibliographie:ArticleID:jn100107
local:jnnp;78/12/1304
href:jnnp-78-1304.pdf
PMID:17400591
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istex:6A9B62154B5B05120C6BAC98AC6C9BB315973B53
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SourceType-Scholarly Journals-1
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ISSN:0022-3050
1468-330X
1468-330X
DOI:10.1136/jnnp.2006.100107