Bronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial)

IntroductionDespite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic feedback on needle positioning, potentially improving...

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Bibliographic Details
Published in:	BMJ open Vol. 14; no. 7; p. e081148
Main Authors:	van Heumen, Saskia, Kramer, Tess, Korevaar, Daniël A, Gompelmann, Daniela, Bal, Christina, Hetzel, Juergen, Jahn, Kathleen, Poletti, Venerino, Ravaglia, Claudia, Sadoughi, Ali, Stratakos, Grigoris, Bakiri, Katerina, Koukaki, Evangelia, Anagnostopoulos, Nektarios, Votruba, Jiří, Šestáková, Zuzana, Heuvelmans, Marjolein A, Daniels, Johannes M.A., de Bruin, Daniel M, Bonta, Peter I, Annema, Jouke T
Format:	Journal Article
Language:	English
Published:	England British Medical Journal Publishing Group 04.07.2024 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Protocol
Subjects:	Biopsy Bronchoscopy Bronchoscopy - methods Cancer therapies Clinical Trial Cytopathology Diagnostic Imaging Feedback Humans Informed consent Lasers Lung - diagnostic imaging Lung - pathology Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Medical diagnosis Medical screening Microscopy, Confocal - methods Multicenter Studies as Topic Needles Patients Randomized Controlled Trials as Topic Respiratory Medicine Respiratory tract tumours Solitary Pulmonary Nodule - diagnosis Solitary Pulmonary Nodule - diagnostic imaging Solitary Pulmonary Nodule - pathology Success Ultrasonic imaging Diagnostic Imaging Respiratory tract tumours Cytopathology Clinical Trial Biopsy
ISSN:	2044-6055, 2044-6055
Online Access:	Get full text
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