Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial

AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. Chil...

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Vydáno v:British journal of ophthalmology Ročník 104; číslo 3; s. 363 - 368
Hlavní autoři: Lam, Carly Siu Yin, Tang, Wing Chun, Tse, Dennis Yan-yin, Lee, Roger Pak Kin, Chun, Rachel Ka Man, Hasegawa, Keigo, Qi, Hua, Hatanaka, Takashi, To, Chi Ho
Médium: Journal Article
Jazyk:angličtina
Vydáno: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.03.2020
BMJ Publishing Group LTD
BMJ Publishing Group
Témata:
Adolescent
Child
Clinical outcomes
Clinical Science
Clinical trials
Disease Progression
Double-Blind Method
Equipment Design
Eyeglasses
Female
Follow-Up Studies
Humans
Male
Myopia
myopia control
Myopia, Degenerative - physiopathology
Myopia, Degenerative - therapy
myopic defocus
Pediatrics
Prospective Studies
Refraction, Ocular - physiology
simultaneous vision
spectacle lens
Time Factors
Treatment Outcome
Hong Kong China
China
myopia
myopic defocus
simultaneous vision
myopia control
spectacle lens
ISSN:0007-1161, 1468-2079, 1468-2079
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Shrnutí:AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia between −1.00 and −5.00 D and astigmatism ≤1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.Results160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were −0.41±0.06 D in the DIMS group and −0.85±0.08 D in the SV group. Mean (SE) axial elongation was 0.21±0.02 mm and 0.55±0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference −0.44±0.09 D, 95% CI −0.73 to −0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34±0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.ConclusionsDaily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.Trial registration number NCT02206217.
Bibliografie:ObjectType-Article-1
ObjectType-Evidence Based Healthcare-3
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-1161
1468-2079
1468-2079
DOI:10.1136/bjophthalmol-2018-313739