Role of the microbiome in human development

The host-microbiome supraorganism appears to have coevolved and the unperturbed microbial component of the dyad renders host health sustainable. This coevolution has likely shaped evolving phenotypes in all life forms on this predominantly microbial planet. The microbiota seems to exert effects on t...

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Bibliographic Details
Published in:Gut Vol. 68; no. 6; pp. 1108 - 1114
Main Authors: Dominguez-Bello, Maria Gloria, Godoy-Vitorino, Filipa, Knight, Rob, Blaser, Martin J
Format: Journal Article
Language:English
Published: England BMJ Publishing Group LTD 01.06.2019
BMJ Publishing Group
Subjects:
Bacteria
Biological Evolution
Coevolution
Deoxyribonucleic acid
Diet
DNA
Environmental conditions
Female
Fetal Development - physiology
Fetuses
Genomes
Gestation
Health Status
Human Development
Humans
Immune response
Immune system
Infant, Newborn
Male
Metabolites
Microbiomes
Microbiota
Microbiota - genetics
Microbiota - physiology
Niches
Phenotypes
Phylogenetics
Physiology
Recent Advances in Basic Science
Skin
United States > US
development
evolution
human microbiome
perturbations
restoration
ISSN:0017-5749, 1468-3288, 1468-3288
Online Access:Get full text
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Summary:The host-microbiome supraorganism appears to have coevolved and the unperturbed microbial component of the dyad renders host health sustainable. This coevolution has likely shaped evolving phenotypes in all life forms on this predominantly microbial planet. The microbiota seems to exert effects on the next generation from gestation, via maternal microbiota and immune responses. The microbiota ecosystems develop, restricted to their epithelial niches by the host immune system, concomitantly with the host chronological development, providing early modulation of physiological host development and functions for nutrition, immunity and resistance to pathogens at all ages. Here, we review the role of the microbiome in human development, including evolutionary considerations, and the maternal/fetal relationships, contributions to nutrition and growth. We also discuss what constitutes a healthy microbiota, how antimicrobial modern practices are impacting the human microbiota, the associations between microbiota perturbations, host responses and diseases rocketing in urban societies and potential for future restoration.
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ISSN:0017-5749
1468-3288
1468-3288
DOI:10.1136/gutjnl-2018-317503