Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study

BackgroundImmunotherapies targeting programmed cell death-1 (PD-1) and its ligands have improved clinical outcomes for advanced melanoma. However, many tumors exhibit primary resistance or acquire secondary resistance after an initial positive response. The mechanisms of resistance are not well unde...

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Veröffentlicht in:	Journal for immunotherapy of cancer Jg. 10; H. 7; S. e004879
Hauptverfasser:	Shui, Irene M., Liu, Xiao Qiao, Zhao, Qing, Kim, Seung Tae, Sun, Yuan, Yearley, Jennifer H., Choudhury, Tasmiah, Webber, Andrea L., Krepler, Clemens, Cristescu, Razvan, Lee, Jeeyun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group Ltd 01.07.2022 BMJ Publishing Group LTD BMJ Publishing Group
Schriftenreihe:	Original research
Schlagworte:	Antigen presentation Apoptosis Biomarkers Biomarkers - analysis Biomarkers, Tumor Cancer Cell death Clinical outcomes Gene expression Humans Immunotherapy Immunotherapy Biomarkers Kinases Melanoma Melanoma - immunology Melanoma - pathology Melanoma - therapy Metastasis Mutation Observational studies Programmed Cell Death 1 Receptor Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Retrospective Studies RNA, Messenger - biosynthesis Tumors Programmed Cell Death 1 Receptor Biomarkers, Tumor Melanoma
ISSN:	2051-1426, 2051-1426
Online-Zugang:	Volltext
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