Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study

BackgroundImmunotherapies targeting programmed cell death-1 (PD-1) and its ligands have improved clinical outcomes for advanced melanoma. However, many tumors exhibit primary resistance or acquire secondary resistance after an initial positive response. The mechanisms of resistance are not well unde...

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Vydáno v:	Journal for immunotherapy of cancer Ročník 10; číslo 7; s. e004879
Hlavní autoři:	Shui, Irene M., Liu, Xiao Qiao, Zhao, Qing, Kim, Seung Tae, Sun, Yuan, Yearley, Jennifer H., Choudhury, Tasmiah, Webber, Andrea L., Krepler, Clemens, Cristescu, Razvan, Lee, Jeeyun
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England BMJ Publishing Group Ltd 01.07.2022 BMJ Publishing Group LTD BMJ Publishing Group
Edice:	Original research
Témata:	Antigen presentation Apoptosis Biomarkers Biomarkers - analysis Biomarkers, Tumor Cancer Cell death Clinical outcomes Gene expression Humans Immunotherapy Immunotherapy Biomarkers Kinases Melanoma Melanoma - immunology Melanoma - pathology Melanoma - therapy Metastasis Mutation Observational studies Programmed Cell Death 1 Receptor Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Retrospective Studies RNA, Messenger - biosynthesis Tumors Programmed Cell Death 1 Receptor Biomarkers, Tumor Melanoma
ISSN:	2051-1426, 2051-1426
On-line přístup:	Získat plný text
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