Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren’s syndrome: association with mononuclear cell infiltration

Objective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjögren’s syndrome, and to relate this organisation to inflammatory cell invasion of acini and ducts. Methods: Immu...

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Vydané v:Annals of the rheumatic diseases Ročník 65; číslo 2; s. 178 - 183
Hlavní autori: Molina, C, Alliende, C, Aguilera, S, Kwon, Y-J, Leyton, L, Martínez, B, Leyton, C, Pérez, P, González, M-J
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.02.2006
BMJ
Elsevier Limited
BMJ Group
Predmet:
Adult
Age
Apoptosis
basal lamina
Basement Membrane - immunology
Basement Membrane - pathology
Biological and medical sciences
Biomarkers - analysis
Biopsy
Case-Control Studies
Chemokines
Chronic Disease
Collagen
Collagen Type IV - analysis
Colleges & universities
Cytokines
Cytotoxicity
Diseases of the osteoarticular system
Extended Report
Female
Grants
Humans
IHR
Immunoglobulins
immunohistochemical reaction
Immunohistochemistry - methods
Laminin - analysis
Lip
Male
matrix metalloproteinase
Medical sciences
Middle Aged
MMP
Morphology
Pancreas
Proteins
Rodents
Salivary Ducts - immunology
Salivary Ducts - pathology
salivary gland
Salivary Glands, Minor - immunology
Salivary Glands, Minor - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sialadenitis - immunology
Sialadenitis - pathology
Sjogren's Syndrome - immunology
Sjogren's Syndrome - pathology
Sjögren’s syndrome
T-Lymphocytes, Cytotoxic - immunology
Human
Eye disease
Mononuclear cell
Stomatology
Labial gland
Systemic disease
Rheumatology
Autoimmune disease
Salivary gland
Infiltration
Sjögren syndrome
ISSN:0003-4967, 1468-2060
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Shrnutí:Objective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjögren’s syndrome, and to relate this organisation to inflammatory cell invasion of acini and ducts. Methods: Immunohistochemistry for laminin and type IV collagen was undertaken on sections of labial salivary glands from 30 patients with Sjögren’s syndrome, 10 control subjects, and 24 controls with chronic sialoadenitis. Immunohistochemistry reaction, alterations to cell morphology, and the presence of inflammatory cells in acini and ducts were evaluated and scored using a semiquantitative method. Results: Changes in the expression of laminin and type IV collagen in the basal lamina of acini and ducts of labial salivary glands from patients with Sjögren’s syndrome were more pronounced than in labial salivary glands from control groups. A remarkable characteristic was the disorganisation of the basal lamina in the labial salivary glands in Sjögren’s syndrome. The pattern of immunoreactivity of the basal lamina of other structures (for example, blood vessels) did not change. In Sjögren’s syndrome, invasion of cytotoxic T lymphocytes was only observed in acini and ducts which had a disorganised basal lamina. Conclusions: The high state of disorganisation of the basal lamina of acini and ducts could allow invasion of cytotoxic T lymphocytes in Sjögren’s syndrome, contributing to cell death and ductal hyperplasia.
Bibliografia:ark:/67375/NVC-VNTP9W6H-8
href:annrheumdis-65-178.pdf
PMID:16014676
local:0650178
istex:AE70DD930123A685647F3C00A86A6AE584AEF187
Correspondence to:
 Professor María-Julieta González
 Programme of Cell and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70061, Santiago 7, Chile; jgonzale@med.uchile.cl
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Copyright © 2006 BMJ Publishing Group Ltd & European League Against Rheumatism
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2004.033837