Long-term dietary quality and risk of developing rheumatoid arthritis in women

ObjectivesTo evaluate the association between long-term dietary quality, measured by the 2010 Alternative Healthy Eating Index, and risk of rheumatoid arthritis (RA) in women.MethodsWe prospectively followed 76 597 women in the Nurses' Health Study aged 30–55 years and 93 392 women in the Nurse...

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Vydané v:Annals of the rheumatic diseases Ročník 76; číslo 8; s. 1357 - 1364
Hlavní autori: Hu, Yang, Sparks, Jeffrey A, Malspeis, Susan, Costenbader, Karen H, Hu, Frank B, Karlson, Elizabeth W, Lu, Bing
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Limited 01.08.2017
Predmet:
Adult
Age
Alcohol
Arthritis, Rheumatoid - epidemiology
Arthritis, Rheumatoid - immunology
Chronic illnesses
Cohort Studies
Connective tissue diseases
Diabetes
Diet
Diet - statistics & numerical data
Diet, Healthy - statistics & numerical data
Disease
Environmental Exposure
Family medical history
Fatty acids
Female
Food
Health risk assessment
Humans
Hypertension
Life Style
Longitudinal Studies
Meat
Medical records
Middle Aged
Multivariate Analysis
Nurses
Proportional Hazards Models
Prospective Studies
Quality
Questionnaires
Rheumatoid arthritis
Rheumatoid Factor - immunology
Rheumatology
Risk Factors
Studies
Womens health
Rheumatoid Arthritis
Ant-CCP
Epidemiology
ISSN:0003-4967, 1468-2060, 1468-2060
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Shrnutí:ObjectivesTo evaluate the association between long-term dietary quality, measured by the 2010 Alternative Healthy Eating Index, and risk of rheumatoid arthritis (RA) in women.MethodsWe prospectively followed 76 597 women in the Nurses' Health Study aged 30–55 years and 93 392 women in the Nurses' Health Study II aged 25–42 years at baseline and free from RA or other connective tissue diseases. The lifestyle, environmental exposure and anthropometric information were collected at baseline and updated biennially. Cumulative follow-up rates were more than 90% for both cohorts. The primary outcome was RA alone with two subtypes of the disease: seropositive and seronegative RA.ResultsDuring 3 678 104 person-years, 1007 RA cases were confirmed. In the multivariable-adjusted model, long-term adherence to healthy eating patterns was marginally associated with reduced RA risk. To assess potential effect modification by age at diagnosis, we stratified by age. Among women aged ≤55 years, better quality diet was associated with lower RA risk (HRQ4 vs Q1: 0.67; 95% CI 0.51 to 0.88; p trend: 0.002), but no significant association was found for women aged >55 years (p interaction: 0.005). When stratifying by serostatus, the inverse association among those aged ≤55 years was strongest for seropositive RA (HRQ4 vs Q1: 0.60; 95% CI 0.42 to 0.86; p trend: 0.003).ConclusionsA healthier diet was associated with a reduced risk of RA occurring at 55 years of age or younger, particularly seropositive RA.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0003-4967
1468-2060
1468-2060
DOI:10.1136/annrheumdis-2016-210431