Frequency doubling technology perimetry in non-arteritic ischaemic optic neuropathy with altitudinal defects

Aim: To determine if frequency doubling technology perimetry (FDT) is more sensitive to optic nerve injury in non-arteritic ischaemic optic neuropathy (NAION) than standard automated perimetry (SAP). Methods: Charts from 18 patients (20 eyes) with NAION with altitudinal defects who underwent a compl...

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Published in:British journal of ophthalmology Vol. 88; no. 10; pp. 1274 - 1279
Main Authors: Girkin, C A, McGwin, G, DeLeon-Ortega, J
Format: Journal Article
Language:English
Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.10.2004
BMJ
BMJ Publishing Group LTD
Copyright 2004 British Journal of Ophthalmology
Subjects:
Adult
Aged
Automation
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical Science - Extended Reports
Confidence intervals
Defects
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Diseases of visual field, optic nerve, optic chiasma and optic tracts
FDT
Female
frequency doubling technology
frequency doubling technology perimetry
Glaucoma
Humans
Male
Medical sciences
Middle Aged
NAION
non-arteritic ischaemic optic neuropathy
Ophthalmology
Optic Disk - pathology
Optic Nerve Diseases - complications
Optic Nerve Diseases - diagnosis
Optic Nerve Diseases - physiopathology
SAP
Scotoma - diagnosis
Scotoma - etiology
Scotoma - physiopathology
SITA
standard achromatic perimetry
Swedish Interactive Thresholding Algorithm
Visual Field Tests - methods
Visual Fields
Nervous system diseases
Optic neuropathy
Cardiovascular disease
Perimetry
Arteritis
Arterial disease
Vascular disease
Eye disease
Cranial nerve disease
Ischemia
Technology
Defect
Frequency
Ophthalmology
ISSN:0007-1161, 1468-2079
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Summary:Aim: To determine if frequency doubling technology perimetry (FDT) is more sensitive to optic nerve injury in non-arteritic ischaemic optic neuropathy (NAION) than standard automated perimetry (SAP). Methods: Charts from 18 patients (20 eyes) with NAION with altitudinal defects who underwent a complete neuro-ophthalmic examination, SAP, and FDT were reviewed. The extent of damage as determined by SAP, FDT, and clinical estimation of the regional extent of optic disc pallor was compared. 10 subjects (20 eyes) with normal ocular examinations and full appearing optic nerve heads were included as a control group. Results: FDT demonstrated more extensive visual field defects in the relatively intact hemifield on SAP (proportion of locations at 5% or worse in the total deviation plot was 8.7% (SD 6.2%) for SAP and 38.3% (39.5%) for FDT p<0.0027). 16 of 20 eyes with altitudinal NAION demonstrated diffuse optic disc pallor. 11 of these eyes with diffuse pallor demonstrated significant defects in both hemifields using FDT, while only two eyes demonstrated diffuse damage using SAP. Correspondence between the extent of optic disc pallor and the extent of visual scotoma was higher for FDT (85%) than with SAP (40%). Conclusion: FDT appears more sensitive to axonal injury reflected by the extent of optic disc pallor in altitudinal NAION than SAP and in some patients reveals visual dysfunction in the hemifield that appeared relatively uninvolved when evaluated using SAP.
Bibliography:istex:1F049935630C78D772F59051F2B55FBC5921DC79
Correspondence to: Christopher Girkin MD Department of Ophthalmology, University of Alabama at Birmingham, Callahan Eye Foundation Hospital, 700 South 18th Street, Suite 601, Birmingham, AL, 35233, USA; cgirkin@uabmc.edu
local:0881274
ark:/67375/NVC-BRM42BGJ-1
PMID:15377550
href:bjophthalmol-88-1274.pdf
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Correspondence to: …Christopher Girkin MD …Department of Ophthalmology, University of Alabama at Birmingham, Callahan Eye Foundation Hospital, 700 South 18th Street, Suite 601, Birmingham, AL, 35233, USA; cgirkin@uabmc.edu
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2004.046383