The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer

IntroductionKidney cancer (renal cell cancer (RCC)) is the seventh most common cancer in the UK. As RCC is largely curable if detected at an early stage and most patients have no symptoms, there is international interest in evaluating a screening programme for RCC. The Yorkshire Kidney Screening Tri...

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Veröffentlicht in:BMJ open Jg. 12; H. 9; S. e063018
Hauptverfasser: Usher-Smith, Juliet A, Godoy, Angela, Burge, Sarah W, Burbidge, Simon, Cartledge, Jon, Crosbie, Philip A J, Eckert, Claire, Farquhar, Fiona, Hammond, David, Hancock, Neil, Iball, Gareth R, Kimuli, Michael, Masson, Golnessa, Neal, Richard D, Rogerson, Suzanne, Rossi, Sabrina H, Sala, Evis, Smith, Andrew, Sharp, Stephen J, Simmonds, Irene, Wallace, Tom, Ward, Matthew, Callister, Matthew E J, Stewart, Grant D
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London British Medical Journal Publishing Group 20.09.2022
BMJ Publishing Group LTD
BMJ Publishing Group
Schriftenreihe:Protocol
Schlagworte:
Abdomen
Asymptomatic
computed tomography
Feasibility studies
Kidney cancer
kidney tumours
Lung cancer
Medical imaging
Medical screening
Pathology
Radiation
urological tumours
Urology
United Kingdom > UK
United States > US
ISSN:2044-6055, 2044-6055
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Zusammenfassung:IntroductionKidney cancer (renal cell cancer (RCC)) is the seventh most common cancer in the UK. As RCC is largely curable if detected at an early stage and most patients have no symptoms, there is international interest in evaluating a screening programme for RCC. The Yorkshire Kidney Screening Trial (YKST) will assess the feasibility of adding non-contrast abdominal CT scanning to screen for RCC and other abdominal pathology within the Yorkshire Lung Screening Trial (YLST), a randomised trial of community-based CT screening for lung cancer.Methods and analysisIn YLST, ever-smokers aged 55–80 years registered with a general practice in Leeds have been randomised to a Lung Health Check assessment, including a thoracic low-dose CT (LDCT) for those at high risk of lung cancer, or routine care. YLST participants randomised to the Lung Health Check arm who attend for the second round of screening at 2 years without a history of RCC or abdominal CT scan within the previous 6 months will be invited to take part in YKST. We anticipate inviting 4700 participants. Those who consent will have an abdominal CT immediately following their YLST thoracic LDCT. A subset of participants and the healthcare workers involved will be invited to take part in a qualitative interview. Primary objectives are to quantify the uptake of the abdominal CT, assess the acceptability of the combined screening approach and pilot the majority of procedures for a subsequent randomised controlled trial of RCC screening within lung cancer screening.Ethics and disseminationYKST was approved by the North West-Preston Research Ethics Committee (21/NW/0021), and the Health Research Authority on 3 February 2021. Trial results will be disseminated at clinical meetings, in peer-reviewed journals and to policy-makers. Findings will be made available to participants via the study website (www.YKST.org).Trial registration numbersNCT05005195 and ISRCTN18055040.
Bibliographie:Protocol
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ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-063018