Role of Matrix Metalloproteinases in Degenerative Kidney Disorders

Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are also known to cleave non-matrix proteins, including cell surface receptors, TNF-α, angiotensin-II, growth factors, (especially...

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Bibliographic Details
Published in:Current medicinal chemistry Vol. 25; no. 15; p. 1805
Main Authors: Narula, Shifa, Tandon, Chanderdeep, Tandon, Simran
Format: Journal Article
Language:English
Published: United Arab Emirates 01.01.2018
Subjects:
Animals
Extracellular Matrix - metabolism
Humans
Kidney Diseases - metabolism
Matrix Metalloproteinases - metabolism
Protein Conformation
Signal Transduction
Tissue Inhibitor of Metalloproteinases - metabolism
Matrix metalloproteinases (MMPs)
fibrosis
renal pathologies
inflammation
tissue inhibitors of metalloproteinases (TIMPs)
extracellular matrix
ISSN:1875-533X, 1875-533X
Online Access:Get more information
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Summary:Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are also known to cleave non-matrix proteins, including cell surface receptors, TNF-α, angiotensin-II, growth factors, (especially transforming growth factor-β1, ΤGF- β1) plasminogen, endothelin and other bioactive molecules. The tissue inhibitors of metalloproteinases (TIMPs) inhibit the activity of MMPs and decrease ECM degradation. Various patho-physiological conditions have been linked with the imbalance of ECM synthesis and degradation. Numerous studies have reported the significance of MMPs and TIMPs in the progression of kidney pathologies, including glomerulonephritis, diabetic nephropathy, renal cancer, and nephrolithiasis. Although dysregulated activity of MMPs could directly or indirectly lead to pathological morbidities, their contribution in disease progression is still understated. Specifically, MMP activity in the kidneys and it's relation to kidney diseases has been the subject of a limited number of investigations. Therefore, the aim of the present review is to provide an updated insight of the involvement of MMPs and TIMPs in the pathogenesis of inflammatory and degenerative kidney disorders.
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ISSN:1875-533X
1875-533X
DOI:10.2174/0929867325666171205143441