Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

ObjectiveThe lack of highly sensitive and specific diagnostic biomarkers is a major contributor to the poor outcomes of patients with hepatocellular carcinoma (HCC). We sought to develop a non-invasive diagnostic approach using circulating cell-free DNA (cfDNA) for the early detection of HCC.DesignA...

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Bibliographic Details
Published in:	Gut Vol. 68; no. 12; pp. 2195 - 2205
Main Authors:	Cai, Jiabin, Chen, Lei, Zhang, Zhou, Zhang, Xinyu, Lu, Xingyu, Liu, Weiwei, Shi, Guoming, Ge, Yang, Gao, Pingting, Yang, Yuan, Ke, Aiwu, Xiao, Linlin, Dong, Ruizhao, Zhu, Yanjing, Yang, Xuan, Wang, Jiefei, Zhu, Tongyu, Yang, Deping, Huang, Xiaowu, Sui, Chengjun, Qiu, Shuangjian, Shen, Feng, Sun, Huichuan, Zhou, Weiping, Zhou, Jian, Nie, Ji, Zeng, Chang, Stroup, Emily Kunce, Zhang, Xu, Chiu, Brian C-H, Lau, Wan Yee, He, Chuan, Wang, Hongyang, Zhang, Wei, Fan, Jia
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.2019 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original article
Subjects:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - blood Biomarkers Biomarkers, Tumor - blood Biopsy cancer Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Cell-Free Nucleic Acids - blood Chronic infection Cirrhosis Clinical outcomes Deoxyribonucleic acid DNA DNA, Neoplasm - analysis Early Detection of Cancer - methods Epigenetics Female Gastroenterology Gene expression Gene mapping Generalized linear models Genome-Wide Association Study - methods Genomes Health care Hepatitis Hepatitis B hepatobiliary cancer Hepatocellular carcinoma Hepatology Hospitals Humans Liver cancer Liver cirrhosis Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - genetics Male Medical prognosis Middle Aged Patients Prospective Studies ROC Curve Signal transduction Surveillance Tumors α-Fetoprotein Chicago Illinois United States > US Illinois China hepatobiliary cancer cancer hepatocellular carcinoma
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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