HCV-related central and peripheral nervous system demyelinating disorders

Chronic infection with hepatitis C virus (HCV) is associated with a large spectrum of extrahepatic manifestations (EHMs), mostly immunologic/rheumatologic in nature owing to B-cell proliferation and clonal expansion. Neurological complications are thought to be immune-mediated or secondary to invasi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Inflammation & allergy drug targets Ročník 13; číslo 5; s. 299
Hlavní autoři: Mariotto, Sara, Ferrari, Sergio, Monaco, Salvatore
Médium: Journal Article
Jazyk:angličtina
Vydáno: United Arab Emirates 01.10.2014
Témata:
Animals
Aquaporin 4 - immunology
Autoantibodies - immunology
B-Lymphocytes - immunology
B-Lymphocytes - virology
Central Nervous System Diseases - etiology
Central Nervous System Diseases - immunology
Demyelinating Diseases - etiology
Demyelinating Diseases - immunology
Hepacivirus - immunology
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - immunology
Humans
Myelin-Associated Glycoprotein - immunology
Neuromyelitis Optica - etiology
Neuromyelitis Optica - immunology
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - immunology
ISSN:2212-4055, 2212-4055
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Chronic infection with hepatitis C virus (HCV) is associated with a large spectrum of extrahepatic manifestations (EHMs), mostly immunologic/rheumatologic in nature owing to B-cell proliferation and clonal expansion. Neurological complications are thought to be immune-mediated or secondary to invasion of neural tissues by HCV, as postulated in transverse myelitis and encephalopathic forms. Primarily axonal neuropathies, including sensorimotor polyneuropathy, large or small fiber sensory neuropathy, motor polyneuropathy, mononeuritis, mononeuritis multiplex, or overlapping syndrome, represent the most common neurological complications of chronic HCV infection. In addition, a number of peripheral demyelinating disorders are encountered, such as chronic inflammatory demyelinating polyneuropathy, the Lewis-Sumner syndrome, and cryoglobulin-associated polyneuropathy with demyelinating features. The spectrum of demyelinating forms also includes rare cases of iatrogenic central and peripheral nervous system disorders, occurring during treatment with pegylated interferon. Herein, we review HCV-related demyelinating conditions, and disclose the novel observation on the significantly increased frequency of chronic demyelinating neuropathy with anti-myelin-associated glycoprotein antibodies in a cohort of 59 consecutive patients recruited at our institution. We also report a second case of neuromyelitis optica with serum IgG autoantibody against the water channel aquaporin-4. The prompt recognition of these atypical and underestimated complications of HCV infection is of crucial importance in deciding which treatment option a patient should be offered.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2212-4055
2212-4055
DOI:10.2174/1871528113666140908113841