Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations

Objective Ulcerative colitis (UC) is a chronic condition characterised by the relapsing inflammation despite previous endoscopic and histological healing. Our objective was to identify the molecular signature associated with UC remission. Design We performed whole-genome transcriptional analysis of...

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Bibliographic Details
Published in:	Gut Vol. 62; no. 7; pp. 967 - 976
Main Authors:	Planell, Núria, Lozano, Juan J, Mora-Buch, Rut, Masamunt, M Carme, Jimeno, Mireya, Ordás, Ingrid, Esteller, Miriam, Ricart, Elena, Piqué, Josep M, Panés, Julián, Salas, Azucena
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.2013 BMJ Publishing Group LTD
Subjects:	Adolescent Adult Age Aged Apoptosis Biomarkers Biopsy Case-Control Studies Cell growth Colitis, Ulcerative - genetics Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon - metabolism Colon - pathology Colorectal cancer Endoscopy Epithelial Cells Epithelial Cells - metabolism Epithelial Cells - pathology Female Gender Gene Expression Gene Expression Profiling - methods Gene Expression Regulation Humans Inflammation Inflammatory bowel disease Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Metabolism Middle Aged Oligonucleotide Array Sequence Analysis - methods Oxidation Remission Induction Reverse Transcriptase Polymerase Chain Reaction - methods Rodents Small intestine Studies Transcriptome Ulcerative Colitis Young Adult Gene Expression Ulcerative Colitis Epithelial Cells
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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