Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

BackgroundTumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate...

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Bibliographic Details
Published in:	Thorax Vol. 73; no. 8; pp. 723 - 730
Main Authors:	Proudfoot, Alastair, Bayliffe, Andrew, O’Kane, Cecilia M, Wright, Tracey, Serone, Adrian, Bareille, Philippe Jean, Brown, Vanessa, Hamid, Umar I, Chen, Younan, Wilson, Robert, Cordy, Joanna, Morley, Peter, de Wildt, Ruud, Elborn, Stuart, Hind, Matthew, Chilvers, Edwin R, Griffiths, Mark, Summers, Charlotte, McAuley, Daniel Francis
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 01.08.2018 BMJ Publishing Group
Series:	Original article
Subjects:	Acute Lung Injury - drug therapy Acute Lung Injury - immunology Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacology Biomarkers, Pharmacological Bronchoalveolar Lavage Fluid - cytology Critical Care Cytokines Dose-Response Relationship, Drug Edema Endothelial Cells - drug effects Flow Cytometry Humans Immunoglobulins Inflammation Inflammation - drug therapy Laboratory animals Lungs Macaca fascicularis Molecular Targeted Therapy Monkeys & apes Nebulizers and Vaporizers Necrosis Neutrophils Pharmacology, Clinical Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors Receptors, Tumor Necrosis Factor, Type I - metabolism Respiratory distress syndrome Sepsis Signal Transduction Studies TNF inhibitors Translational Research, Biomedical Tumor necrosis factor-TNF Ventilation Ventilators neutrophil biology ARDS
ISSN:	0040-6376, 1468-3296, 1468-3296
Online Access:	Get full text
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