Anti-inflammatory approaches to ischaemic stroke prevention

Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we sum...

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Vydáno v:	Journal of neurology, neurosurgery and psychiatry Ročník 89; číslo 2; s. 211 - 218
Hlavní autoři:	Kelly, Peter J, Murphy, Sean, Coveney, Sarah, Purroy, Francisco, Lemmens, Robin, Tsivgoulis, Georgios, Price, Chris
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England BMJ Publishing Group LTD 01.02.2018
Témata:	Anti-Inflammatory Agents - therapeutic use Atherosclerosis Brain Ischemia - immunology Brain Ischemia - prevention & control C-Reactive Protein - immunology Cardiac arrhythmia Cardiovascular disease Clinical trials Colchicine - therapeutic use Coronary Disease - immunology Coronary vessels Dementia Disease prevention Embolisms Health risk assessment Heart attacks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Inflammation - immunology Intracranial Arteriosclerosis - immunology Plaque, Atherosclerotic - immunology Proteins Recurrence Stroke Stroke - immunology Stroke - prevention & control Studies Systematic review Uric acid stroke
ISSN:	0022-3050, 1468-330X, 1468-330X
On-line přístup:	Získat plný text
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Shrnutí:	Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we summarise the evidence linking inflammation to stroke risk and discuss clinical trials addressing the ’inflammation hypothesis' in coronary disease and stroke. Trial registration number CONVINCE trial ClinicalTrials.gov number; NCT 02898610; Pre-results.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0022-3050 1468-330X 1468-330X
DOI:	10.1136/jnnp-2016-314817