Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy

ObjectiveThe gain of function (GOF) CTNNB1 mutations (CTNNB1GOF) in hepatocellular carcinoma (HCC) cause significant immune escape and resistance to anti-PD-1. Here, we aimed to investigate the mechanism of CTNNB1GOF HCC-mediated immune escape and raise a new therapeutic strategy to enhance anti-PD-...

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Bibliographic Details
Published in:	Gut Vol. 73; no. 6; pp. 985 - 999
Main Authors:	Cai, Ning, Cheng, Kun, Ma, Yue, Liu, Sha, Tao, Ran, Li, Yani, Li, Danfeng, Guo, Bin, Jia, Wenlong, Liang, Huifang, Zhao, Jianping, Xia, Limin, Ding, Ze-yang, Chen, Jinhong, Zhang, Wanguang
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.06.2024 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original research
Subjects:	Animal models Animals beta Catenin - genetics beta Catenin - metabolism CANCER IMMUNOBIOLOGY Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cell-mediated immunity Chemokine receptors Chemokines Consortia CXCR3 protein Cytotoxicity Datasets Dendritic cells Down-regulation Flow cytometry G protein-coupled receptors Gelatinase B Gene flow Genes Genomes HEPATOCELLULAR CARCINOMA Hepatology Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immune evasion IMMUNOTHERAPY Intracellular signalling Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - immunology Liver Neoplasms - pathology Lymphocytes Lymphocytes T Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical prognosis Metalloproteinase Metastases Mice Microenvironments Mutation MUTATIONS PD-1 protein Phosphoprotein phosphatase Plasmids Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Protein phosphatase Proteins Proteomics Transcription activation Tumor Escape - drug effects Tumor Escape - genetics Tumor Microenvironment - immunology Tumors β-Catenin CANCER IMMUNOBIOLOGY MUTATIONS IMMUNOTHERAPY HEPATOCELLULAR CARCINOMA
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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