Longitudinal assessment of excessive daytime sleepiness in early Parkinson’s disease
BackgroundExcessive daytime sleepiness (EDS) is common and disabling in Parkinson’s disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness i...
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| Published in: | Journal of neurology, neurosurgery and psychiatry Vol. 88; no. 8; pp. 653 - 662 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
BMJ Publishing Group LTD
01.08.2017
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| ISSN: | 0022-3050, 1468-330X, 1468-330X |
| Online Access: | Get full text |
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| Abstract | BackgroundExcessive daytime sleepiness (EDS) is common and disabling in Parkinson’s disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD.MethodsThe Parkinson’s Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196). EDS was measured with the Epworth Sleepiness Scale (ESS). Clinical, biological and imaging variables were assessed for associations with EDS for up to 3 years. A machine learning approach (random survival forests) was used to investigate baseline predictors of incident EDS.ResultsESS increased in PD from baseline to year 3 (mean±SD 5.8±3.5 to 7.55±4.6, p<0.0001), with no change in HC. Longitudinally, EDS in PD was associated with non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but not cognitive dysfunction or motor severity. Dopaminergic therapy was associated with EDS at years 2 and 3, as dose increased. EDS was also associated with presynaptic dopaminergic dysfunction, whereas biofluid markers at year 1 showed no significant associations with EDS. A predictive index for EDS was generated, which included seven baseline characteristics, including non-motor symptoms and cerebrospinal fluid phosphorylated-tau/total-tau ratio.ConclusionsIn early PD, EDS increases significantly over time and is associated with several clinical variables. The influence of dopaminergic therapy on EDS is dose dependent. Further longitudinal analyses will better characterise associations with imaging and biomarkers. |
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| AbstractList | Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD.
The Parkinson's Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196). EDS was measured with the Epworth Sleepiness Scale (ESS). Clinical, biological and imaging variables were assessed for associations with EDS for up to 3 years. A machine learning approach (random survival forests) was used to investigate baseline predictors of incident EDS.
ESS increased in PD from baseline to year 3 (mean±SD 5.8±3.5 to 7.55±4.6, p<0.0001), with no change in HC. Longitudinally, EDS in PD was associated with non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but not cognitive dysfunction or motor severity. Dopaminergic therapy was associated with EDS at years 2 and 3, as dose increased. EDS was also associated with presynaptic dopaminergic dysfunction, whereas biofluid markers at year 1 showed no significant associations with EDS. A predictive index for EDS was generated, which included seven baseline characteristics, including non-motor symptoms and cerebrospinal fluid phosphorylated-tau/total-tau ratio.
In early PD, EDS increases significantly over time and is associated with several clinical variables. The influence of dopaminergic therapy on EDS is dose dependent. Further longitudinal analyses will better characterise associations with imaging and biomarkers. Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD.BACKGROUNDExcessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD.The Parkinson's Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196). EDS was measured with the Epworth Sleepiness Scale (ESS). Clinical, biological and imaging variables were assessed for associations with EDS for up to 3 years. A machine learning approach (random survival forests) was used to investigate baseline predictors of incident EDS.METHODSThe Parkinson's Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196). EDS was measured with the Epworth Sleepiness Scale (ESS). Clinical, biological and imaging variables were assessed for associations with EDS for up to 3 years. A machine learning approach (random survival forests) was used to investigate baseline predictors of incident EDS.ESS increased in PD from baseline to year 3 (mean±SD 5.8±3.5 to 7.55±4.6, p<0.0001), with no change in HC. Longitudinally, EDS in PD was associated with non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but not cognitive dysfunction or motor severity. Dopaminergic therapy was associated with EDS at years 2 and 3, as dose increased. EDS was also associated with presynaptic dopaminergic dysfunction, whereas biofluid markers at year 1 showed no significant associations with EDS. A predictive index for EDS was generated, which included seven baseline characteristics, including non-motor symptoms and cerebrospinal fluid phosphorylated-tau/total-tau ratio.RESULTSESS increased in PD from baseline to year 3 (mean±SD 5.8±3.5 to 7.55±4.6, p<0.0001), with no change in HC. Longitudinally, EDS in PD was associated with non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but not cognitive dysfunction or motor severity. Dopaminergic therapy was associated with EDS at years 2 and 3, as dose increased. EDS was also associated with presynaptic dopaminergic dysfunction, whereas biofluid markers at year 1 showed no significant associations with EDS. A predictive index for EDS was generated, which included seven baseline characteristics, including non-motor symptoms and cerebrospinal fluid phosphorylated-tau/total-tau ratio.In early PD, EDS increases significantly over time and is associated with several clinical variables. The influence of dopaminergic therapy on EDS is dose dependent. Further longitudinal analyses will better characterise associations with imaging and biomarkers.CONCLUSIONSIn early PD, EDS increases significantly over time and is associated with several clinical variables. The influence of dopaminergic therapy on EDS is dose dependent. Further longitudinal analyses will better characterise associations with imaging and biomarkers. BackgroundExcessive daytime sleepiness (EDS) is common and disabling in Parkinson’s disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD.MethodsThe Parkinson’s Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196). EDS was measured with the Epworth Sleepiness Scale (ESS). Clinical, biological and imaging variables were assessed for associations with EDS for up to 3 years. A machine learning approach (random survival forests) was used to investigate baseline predictors of incident EDS.ResultsESS increased in PD from baseline to year 3 (mean±SD 5.8±3.5 to 7.55±4.6, p<0.0001), with no change in HC. Longitudinally, EDS in PD was associated with non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but not cognitive dysfunction or motor severity. Dopaminergic therapy was associated with EDS at years 2 and 3, as dose increased. EDS was also associated with presynaptic dopaminergic dysfunction, whereas biofluid markers at year 1 showed no significant associations with EDS. A predictive index for EDS was generated, which included seven baseline characteristics, including non-motor symptoms and cerebrospinal fluid phosphorylated-tau/total-tau ratio.ConclusionsIn early PD, EDS increases significantly over time and is associated with several clinical variables. The influence of dopaminergic therapy on EDS is dose dependent. Further longitudinal analyses will better characterise associations with imaging and biomarkers. Background Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD. Methods The Parkinson's Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196). EDS was measured with the Epworth Sleepiness Scale (ESS). Clinical, biological and imaging variables were assessed for associations with EDS for up to 3 years. A machine learning approach (random survival forests) was used to investigate baseline predictors of incident EDS. Results ESS increased in PD from baseline to year 3 (mean±SD 5.8±3.5 to 7.55±4.6, p<0.0001), with no change in HC. Longitudinally, EDS in PD was associated with non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour disorder, but not cognitive dysfunction or motor severity. Dopaminergic therapy was associated with EDS at years 2 and 3, as dose increased. EDS was also associated with presynaptic dopaminergic dysfunction, whereas biofluid markers at year 1 showed no significant associations with EDS. A predictive index for EDS was generated, which included seven baseline characteristics, including non-motor symptoms and cerebrospinal fluid phosphorylated-tau/total-tau ratio. Conclusions In early PD, EDS increases significantly over time and is associated with several clinical variables. The influence of dopaminergic therapy on EDS is dose dependent. Further longitudinal analyses will better characterise associations with imaging and biomarkers. |
| Author | Amara, Amy W Iranzo, Alex Videnovic, Aleksandar Postuma, Ron Foldvary-Schaefer, Nancy Marek, Ken Long, Jeffrey D Oertel, Wolfgang Högl, Birgit Mayer, Geert Chahine, Lama M Caspell-Garcia, Chelsea Coffey, Christopher Simuni, Tanya Lasch, Shirley |
| AuthorAffiliation | 10 Department of Neurology, Philipps University, Marburg, Germany 6 Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain 4 Department of Neurology, Innsbruck Medical University, Innsbruck, Austria 1 Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA 3 Department of Biostatistics, The University of Iowa, Iowa City, Iowa, USA 11 Charitable Hertie Foundation, Frankfurt, Germany 8 Cleveland Clinic Neurological Institute, Cleveland, Ohio, USA 5 Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA 12 Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA 9 Division of Neurology, McGill University, Montreal, Québec, Canada 2 Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA 7 Department of Neurology, Hephata-Klinik,Hephata Hessisches Diakoniezentrum, e.V., Schwalmstadt-Treysa, Germany 13 Department of Neurology, Northwest |
| AuthorAffiliation_xml | – name: 9 Division of Neurology, McGill University, Montreal, Québec, Canada – name: 4 Department of Neurology, Innsbruck Medical University, Innsbruck, Austria – name: 11 Charitable Hertie Foundation, Frankfurt, Germany – name: 3 Department of Biostatistics, The University of Iowa, Iowa City, Iowa, USA – name: 7 Department of Neurology, Hephata-Klinik,Hephata Hessisches Diakoniezentrum, e.V., Schwalmstadt-Treysa, Germany – name: 5 Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA – name: 6 Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain – name: 13 Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA – name: 1 Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA – name: 2 Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA – name: 8 Cleveland Clinic Neurological Institute, Cleveland, Ohio, USA – name: 10 Department of Neurology, Philipps University, Marburg, Germany – name: 12 Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA |
| Author_xml | – sequence: 1 givenname: Amy W surname: Amara fullname: Amara, Amy W email: amyamara@uab.edu organization: Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA – sequence: 2 givenname: Lama M surname: Chahine fullname: Chahine, Lama M email: amyamara@uab.edu organization: Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA – sequence: 3 givenname: Chelsea surname: Caspell-Garcia fullname: Caspell-Garcia, Chelsea email: amyamara@uab.edu organization: Department of Biostatistics, The University of Iowa, Iowa City, Iowa, USA – sequence: 4 givenname: Jeffrey D surname: Long fullname: Long, Jeffrey D email: amyamara@uab.edu organization: Department of Biostatistics, The University of Iowa, Iowa City, Iowa, USA – sequence: 5 givenname: Christopher surname: Coffey fullname: Coffey, Christopher email: amyamara@uab.edu organization: Department of Biostatistics, The University of Iowa, Iowa City, Iowa, USA – sequence: 6 givenname: Birgit surname: Högl fullname: Högl, Birgit email: amyamara@uab.edu organization: Department of Neurology, Innsbruck Medical University, Innsbruck, Austria – sequence: 7 givenname: Aleksandar surname: Videnovic fullname: Videnovic, Aleksandar email: amyamara@uab.edu organization: Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA – sequence: 8 givenname: Alex surname: Iranzo fullname: Iranzo, Alex email: amyamara@uab.edu organization: Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain – sequence: 9 givenname: Geert surname: Mayer fullname: Mayer, Geert email: amyamara@uab.edu organization: Department of Neurology, Hephata-Klinik, Hephata Hessisches Diakoniezentrum, e.V., Schwalmstadt-Treysa, Germany – sequence: 10 givenname: Nancy surname: Foldvary-Schaefer fullname: Foldvary-Schaefer, Nancy email: amyamara@uab.edu organization: Cleveland Clinic Neurological Institute, Cleveland, Ohio, USA – sequence: 11 givenname: Ron surname: Postuma fullname: Postuma, Ron email: amyamara@uab.edu organization: Division of Neurology, McGill University, Montreal, Québec, Canada – sequence: 12 givenname: Wolfgang surname: Oertel fullname: Oertel, Wolfgang email: amyamara@uab.edu organization: Charitable Hertie Foundation, Frankfurt, Germany – sequence: 13 givenname: Shirley surname: Lasch fullname: Lasch, Shirley email: amyamara@uab.edu organization: Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA – sequence: 14 givenname: Ken surname: Marek fullname: Marek, Ken email: amyamara@uab.edu organization: Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA – sequence: 15 givenname: Tanya surname: Simuni fullname: Simuni, Tanya email: amyamara@uab.edu organization: Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28554959$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1159/000276402 10.1002/mds.25832 10.1007/s11910-013-0377-9 10.1016/j.parkreldis.2012.05.022 10.1016/j.parkreldis.2016.01.020 10.1002/acn3.317 10.1016/j.parkreldis.2015.09.027 10.1016/j.smrv.2016.08.001 10.1212/WNL.0000000000001737 10.1002/mds.23462 10.1111/j.1532-5415.2005.53221.x 10.1002/mds.23190 10.1002/mds.26248 10.1097/01.JGP.0000192488.66049.4b 10.1016/j.pneurobio.2011.09.005 10.1001/jamaneurol.2013.3861 10.1007/s00415-006-0483-6 10.1002/mds.21727 10.1212/WNL.0000000000000842 10.1016/j.sleep.2005.12.002 10.1186/1471-2288-14-40 10.1212/01.wnl.0000233980.25978.9d 10.1002/mds.20412 10.1002/mds.25383 10.1214/08-AOAS169 10.1002/mds.23429 10.5664/jcsm.4598 10.1111/j.1468-1331.2009.02788.x 10.1002/mds.21537 10.1002/mds.21740 10.1002/mds.24023 10.1093/aje/kwq478 10.5665/sleep.5040 10.1002/mds.22340 10.1111/j.1365-2869.2012.01027.x 10.1111/j.1365-2869.2007.00570.x 10.1002/ana.410380407 10.1002/mds.26510 10.1007/s00415-011-6187-6 10.1002/mds.25187 10.1002/mds.23763 10.1136/jnnp-2012-304097 10.1212/WNL.58.7.1019 10.1093/sleep/14.6.540 10.1007/s11910-996-0041-8 10.1212/WNL.17.5.427 10.1016/S0197-4580(02)00065-9 10.1037/0022-006X.44.3.406 |
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| ISSN | 0022-3050 1468-330X |
| IngestDate | Tue Nov 04 02:00:19 EST 2025 Thu Sep 04 19:55:16 EDT 2025 Tue Oct 07 07:27:25 EDT 2025 Thu Apr 03 06:58:55 EDT 2025 Tue Nov 18 21:08:30 EST 2025 Sat Nov 29 02:37:13 EST 2025 Thu Apr 24 23:07:14 EDT 2025 |
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| Issue | 8 |
| Keywords | Biomarkers Excessive daytime sleepiness Non-motor symptoms Sleep Parkinson’s disease |
| Language | English |
| License | Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Contributors AWA: research project: conception and execution; statistical analysis: review and critique; manuscript preparation:writing the first draft, review and critique. LMC: research project:conception; statistical analysis: review and critique; manuscript preparation:drafting/revising manuscript and review and critique. CC-G and JDL: statistical analysis: design, execution and review and critique; manuscript preparation:review and critique. CC: statistical analysis: review and critique; manuscript preparation: review and critique. BH and AV: research project: conception;statistical analysis: review and critique; manuscript preparation: review and critique. AI: research project: organisation; statistical analysis: review and critique; manuscript preparation: review and critique. GM: research project:conception and execution; manuscript preparation: review and critique. NF-S:manuscript preparation: review and critique. RP: statistical analysis: review and critique; manuscript preparation: review and critique. WO: research project: conception and organisation; statistical analysis: review and critique; manuscript preparation: review and critique. SL: research project:conception, organisation and execution; statistical analysis: review and critique; manuscript preparation: review and critique. KM: research project:conception, organisation and execution; statistical analysis: design and review and critique; manuscript preparation: review and critique. TS: research project: conception, organisation and execution; statistical analysis: designand review and critique: manuscript preparation: drafting and review and critique. |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/7282477 |
| PMID | 28554959 |
| PQID | 1918791083 |
| PQPubID | 2041879 |
| PageCount | 10 |
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| PublicationDate | 2017-08-01 |
| PublicationDateYYYYMMDD | 2017-08-01 |
| PublicationDate_xml | – month: 08 year: 2017 text: 2017-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Journal of neurology, neurosurgery and psychiatry |
| PublicationTitleAlternate | J Neurol Neurosurg Psychiatry |
| PublicationYear | 2017 |
| Publisher | BMJ Publishing Group LTD |
| Publisher_xml | – name: BMJ Publishing Group LTD |
| References | Seibyl, Marek, Quinlan 1995; 38 Martinez-Martin, Rodriguez-Blazquez, Kurtis 2011; 26 Monaca, Duhamel, Jacquesson 2006; 7 Marras, Chaudhuri 2016; 31 Stiasny-Kolster, Mayer, Schäfer 2007; 22 Collins, de Groot, Dutton 2014; 14 Bogan, Roth, Schwartz 2015; 11 Arnulf, Konofal, Merino-Andreu 2002; 58 Kato, Watanabe, Senda 2012; 259 Arnulf, Neutel, Herlin 2015; 38 Müller, Bohnen 2013; 13 Gao, Huang, Park 2011; 173 Hoehn, Yahr 1967; 17 Simuni, Caspell-Garcia, Coffey 2015; 30 Knipe, Wickremaratchi, Wyatt-Haines 2011; 26 Chahine, Amara, Videnovic 2016 Verbaan, van Rooden, Visser 2008; 23 Weintraub, Oehlberg, Katz 2006; 14 Tomlinson, Stowe, Patel 2010; 25 Rodriguez-Blazquez, Forjaz, Frades-Payo 2010; 17 Bolitho, Naismith, Terpening 2014; 29 Gjerstad, Alves, Wentzel-Larsen 2006; 67 Ishwaran, Kogalur, Blackstone 2008; 2 Kendall, Finch, Auerbach 1976; 44 Nasreddine, Phillips, Bédirian 2005; 53 Wienecke, Werth, Poryazova 2012; 21 Post, Merkus, de Haan 2007; 22 Sauerbier, Jenner, Todorova 2016; 22 2011; 95 Högl, Arnulf, Comella 2010; 25 Rye 2006; 6 Hagell, Broman 2007; 16 Simuni, Long, Caspell-Garcia 2016; 3 Happe, Baier, Helmschmied 2007; 254 Poryazova, Benninger, Waldvogel 2010; 63 Anang, Gagnon, Bertrand 2014; 83 Erro, Pappatà, Amboni 2012; 18 Kang, Irwin, Chen-Plotkin 2013; 70 Johns 1991; 14 Stebbins, Goetz, Burn 2013; 28 Meindorfner, Körner, Möller 2005; 20 Zhu, van Hilten, Marinus 2016; 24 Weintraub, Mamikonyan, Papay 2012; 27 Sulzer, Surmeier 2013; 28 Breen, Williams-Gray, Mason 2013; 84 Tholfsen, Larsen, Schulz 2015; 85 Goetz, Tilley, Shaftman 2008; 23 Braak, Del Tredici, Rüb 2003; 24 Marras (key-10.1136/jnnp-2016-315023-43) 2016; 31 Wienecke (key-10.1136/jnnp-2016-315023-49) 2012; 21 Simuni (key-10.1136/jnnp-2016-315023-35) 2016; 3 Hagell (key-10.1136/jnnp-2016-315023-16) 2007; 16 Breen (key-10.1136/jnnp-2016-315023-7) 2013; 84 Meindorfner (key-10.1136/jnnp-2016-315023-5) 2005; 20 Gjerstad (key-10.1136/jnnp-2016-315023-12) 2006; 67 Högl (key-10.1136/jnnp-2016-315023-19) 2010; 25 Johns (key-10.1136/jnnp-2016-315023-15) 1991; 14 Collins (key-10.1136/jnnp-2016-315023-36) 2014; 14 Kang (key-10.1136/jnnp-2016-315023-33) 2013; 70 Erro (key-10.1136/jnnp-2016-315023-46) 2012; 18 Monaca (key-10.1136/jnnp-2016-315023-17) 2006; 7 Gao (key-10.1136/jnnp-2016-315023-14) 2011; 173 Simuni (key-10.1136/jnnp-2016-315023-2) 2015; 30 Post (key-10.1136/jnnp-2016-315023-39) 2007; 22 Zhu (key-10.1136/jnnp-2016-315023-6) 2016; 24 Rye (key-10.1136/jnnp-2016-315023-9) 2006; 6 Müller (key-10.1136/jnnp-2016-315023-40) 2013; 13 Poryazova (key-10.1136/jnnp-2016-315023-18) 2010; 63 Chahine (key-10.1136/jnnp-2016-315023-4) 2016 Braak (key-10.1136/jnnp-2016-315023-42) 2003; 24 Weintraub (key-10.1136/jnnp-2016-315023-26) 2006; 14 Sauerbier (key-10.1136/jnnp-2016-315023-44) 2016; 22 Stiasny-Kolster (key-10.1136/jnnp-2016-315023-30) 2007; 22 Martinez-Martin (key-10.1136/jnnp-2016-315023-1) 2011; 26 Bolitho (key-10.1136/jnnp-2016-315023-31) 2014; 29 Rodriguez-Blazquez (key-10.1136/jnnp-2016-315023-27) 2010; 17 Tomlinson (key-10.1136/jnnp-2016-315023-32) 2010; 25 Goetz (key-10.1136/jnnp-2016-315023-21) 2008; 23 Ishwaran (key-10.1136/jnnp-2016-315023-34) 2008; 2 Anang (key-10.1136/jnnp-2016-315023-45) 2014; 83 Tholfsen (key-10.1136/jnnp-2016-315023-13) 2015; 85 Kato (key-10.1136/jnnp-2016-315023-10) 2012; 259 Knipe (key-10.1136/jnnp-2016-315023-3) 2011; 26 Sulzer (key-10.1136/jnnp-2016-315023-41) 2013; 28 Weintraub (key-10.1136/jnnp-2016-315023-29) 2012; 27 Arnulf (key-10.1136/jnnp-2016-315023-38) 2015; 38 Parkinson Progression Marker Initiative (key-10.1136/jnnp-2016-315023-11) 2011; 95 Nasreddine (key-10.1136/jnnp-2016-315023-25) 2005; 53 Kendall (key-10.1136/jnnp-2016-315023-28) 1976; 44 Stebbins (key-10.1136/jnnp-2016-315023-22) 2013; 28 Schwab (key-10.1136/jnnp-2016-315023-24) 1969 Hoehn (key-10.1136/jnnp-2016-315023-23) 1967; 17 Bogan (key-10.1136/jnnp-2016-315023-37) 2015; 11 Arnulf (key-10.1136/jnnp-2016-315023-20) 2002; 58 Seibyl (key-10.1136/jnnp-2016-315023-47) 1995; 38 Happe (key-10.1136/jnnp-2016-315023-48) 2007; 254 Verbaan (key-10.1136/jnnp-2016-315023-8) 2008; 23 |
| References_xml | – volume: 63 start-page: 129 year: 2010 article-title: Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants publication-title: Eur Neurol doi: 10.1159/000276402 – volume: 58 start-page: 1019 year: 2002 article-title: Parkinson's disease and sleepiness: an integral part of PD publication-title: Neurology – volume: 29 start-page: 736 year: 2014 article-title: Investigating rapid eye movement sleep without atonia in Parkinson's disease using the rapid eye movement sleep behavior disorder screening questionnaire publication-title: Mov Disord doi: 10.1002/mds.25832 – volume: 13 start-page: 377 year: 2013 article-title: Cholinergic dysfunction in Parkinson's disease publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-013-0377-9 – volume: 18 start-page: 1034 year: 2012 article-title: Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2012.05.022 – volume: 24 start-page: 34 year: 2016 article-title: Course and risk factors for excessive daytime sleepiness in Parkinson's disease publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2016.01.020 – volume: 14 start-page: 540 year: 1991 article-title: A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale publication-title: Sleep – volume: 3 start-page: 482 year: 2016 article-title: Predictors of time to initiation of symptomatic therapy in early Parkinson's disease publication-title: Ann Clin Transl Neurol doi: 10.1002/acn3.317 – volume: 22 start-page: S41 issue: Suppl 1 year: 2016 article-title: Non motor subtypes and Parkinson's disease publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2015.09.027 – year: 2016 article-title: A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015 publication-title: Sleep Med Rev doi: 10.1016/j.smrv.2016.08.001 – volume: 85 start-page: 162 year: 2015 article-title: Development of excessive daytime sleepiness in early Parkinson disease publication-title: Neurology doi: 10.1212/WNL.0000000000001737 – volume: 26 start-page: 399 year: 2011 article-title: The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.23462 – volume: 17 start-page: 427 year: 1967 article-title: Parkinsonism: onset, progression and mortality publication-title: Neurology – volume: 53 start-page: 695 year: 2005 article-title: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2005.53221.x – volume: 25 start-page: 2704 year: 2010 article-title: Scales to assess sleep impairment in Parkinson's disease: critique and recommendations publication-title: Mov Disord doi: 10.1002/mds.23190 – volume: 30 start-page: 1371 year: 2015 article-title: Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study publication-title: Mov Disord doi: 10.1002/mds.26248 – volume: 14 start-page: 169 year: 2006 article-title: Test characteristics of the 15-item Geriatric Depression Scale and Hamilton Depression Rating Scale in Parkinson disease publication-title: Am J Geriatr Psychiatry doi: 10.1097/01.JGP.0000192488.66049.4b – volume: 95 start-page: 629 year: 2011 article-title: The Parkinson Progression Marker Initiative (PPMI) publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2011.09.005 – volume: 70 start-page: 1277 year: 2013 article-title: Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2013.3861 – volume: 254 start-page: 1037 year: 2007 article-title: Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's disease publication-title: J Neurol doi: 10.1007/s00415-006-0483-6 – volume: 23 start-page: 35 year: 2008 article-title: Nighttime sleep problems and daytime sleepiness in Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.21727 – volume: 83 start-page: 1253 year: 2014 article-title: Predictors of dementia in Parkinson disease: a prospective cohort study publication-title: Neurology doi: 10.1212/WNL.0000000000000842 – volume: 7 start-page: 448 year: 2006 article-title: Vigilance troubles in Parkinson's disease: a subjective and objective polysomnographic study publication-title: Sleep Med doi: 10.1016/j.sleep.2005.12.002 – volume: 14 start-page: 40 year: 2014 article-title: External validation of multivariable prediction models: a systematic review of methodological conduct and reporting publication-title: BMC Med Res Methodol doi: 10.1186/1471-2288-14-40 – volume: 67 start-page: 853 year: 2006 article-title: Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? publication-title: Neurology doi: 10.1212/01.wnl.0000233980.25978.9d – volume: 20 start-page: 832 year: 2005 article-title: Driving in Parkinson's disease: mobility, accidents, and sudden onset of sleep at the wheel publication-title: Mov Disord doi: 10.1002/mds.20412 – volume: 28 start-page: 668 year: 2013 article-title: How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale publication-title: Mov Disord doi: 10.1002/mds.25383 – volume: 2 start-page: 841 year: 2008 article-title: Random survival forests publication-title: Ann Appl Stat doi: 10.1214/08-AOAS169 – volume: 25 start-page: 2649 year: 2010 article-title: Systematic review of levodopa dose equivalency reporting in Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.23429 – volume: 11 start-page: 427 year: 2015 article-title: Time to response with sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy publication-title: J Clin Sleep Med doi: 10.5664/jcsm.4598 – volume: 17 start-page: 194 year: 2010 article-title: Independent validation of the scales for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT) publication-title: Eur J Neurol doi: 10.1111/j.1468-1331.2009.02788.x – volume: 22 start-page: 1839 year: 2007 article-title: Prognostic factors for the progression of Parkinson's disease: a systematic review publication-title: Mov Disord doi: 10.1002/mds.21537 – volume: 22 start-page: 2386 year: 2007 article-title: The REM sleep behavior disorder screening questionnaire—a new diagnostic instrument publication-title: Mov Disord doi: 10.1002/mds.21740 – volume: 27 start-page: 242 year: 2012 article-title: Questionnaire for Impulsive-Compulsive disorders in Parkinson's Disease-Rating Scale publication-title: Mov Disord doi: 10.1002/mds.24023 – volume: 173 start-page: 1032 year: 2011 article-title: Daytime napping, nighttime sleeping, and Parkinson disease publication-title: Am J Epidemiol doi: 10.1093/aje/kwq478 – volume: 38 start-page: 1529 year: 2015 article-title: Sleepiness in Idiopathic REM sleep behavior disorder and Parkinson disease publication-title: Sleep doi: 10.5665/sleep.5040 – volume: 23 start-page: 2129 year: 2008 article-title: Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results publication-title: Mov Disord doi: 10.1002/mds.22340 – volume: 21 start-page: 710 year: 2012 article-title: Progressive dopamine and hypocretin deficiencies in Parkinson's disease: is there an impact on sleep and wakefulness? publication-title: J Sleep Res doi: 10.1111/j.1365-2869.2012.01027.x – volume: 24 start-page: 197 year: 2003 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol Aging – volume: 16 start-page: 102 year: 2007 article-title: Measurement properties and hierarchical item structure of the Epworth Sleepiness Scale in Parkinson's disease publication-title: J Sleep Res doi: 10.1111/j.1365-2869.2007.00570.x – volume: 38 start-page: 589 year: 1995 article-title: Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease publication-title: Ann Neurol doi: 10.1002/ana.410380407 – volume: 44 start-page: 406 year: 1976 article-title: The State-Trait Anxiety Inventory: a systematic evaluation publication-title: J Consult Clin Psychol – volume: 31 start-page: 1095 year: 2016 article-title: Nonmotor features of Parkinson's disease subtypes publication-title: Mov Disord doi: 10.1002/mds.26510 – volume: 6 start-page: 169 year: 2006 article-title: Excessive daytime sleepiness and unintended sleep in Parkinson's disease publication-title: Curr Neurol Neurosci Rep – volume: 259 start-page: 318 year: 2012 article-title: Widespread cortical and subcortical brain atrophy in Parkinson's disease with excessive daytime sleepiness publication-title: J Neurol doi: 10.1007/s00415-011-6187-6 – volume: 28 start-page: 715 year: 2013 article-title: Neuronal vulnerability, pathogenesis, and Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.25187 – volume: 26 start-page: 2011 year: 2011 article-title: Quality of life in young- compared with late-onset Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.23763 – volume: 84 start-page: 233 year: 2013 article-title: Excessive daytime sleepiness and its risk factors in incident Parkinson's disease publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2012-304097 – volume: 63 start-page: 129 year: 2010 ident: key-10.1136/jnnp-2016-315023-18 article-title: Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants publication-title: Eur Neurol doi: 10.1159/000276402 – volume: 38 start-page: 1529 year: 2015 ident: key-10.1136/jnnp-2016-315023-38 article-title: Sleepiness in Idiopathic REM sleep behavior disorder and Parkinson disease publication-title: Sleep doi: 10.5665/sleep.5040 – volume: 22 start-page: S41 issue: Suppl 1 year: 2016 ident: key-10.1136/jnnp-2016-315023-44 article-title: Non motor subtypes and Parkinson's disease publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2015.09.027 – volume: 95 start-page: 629 year: 2011 ident: key-10.1136/jnnp-2016-315023-11 article-title: The Parkinson Progression Marker Initiative (PPMI) publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2011.09.005 – volume: 58 start-page: 1019 year: 2002 ident: key-10.1136/jnnp-2016-315023-20 article-title: Parkinson's disease and sleepiness: an integral part of PD publication-title: Neurology doi: 10.1212/WNL.58.7.1019 – volume: 84 start-page: 233 year: 2013 ident: key-10.1136/jnnp-2016-315023-7 article-title: Excessive daytime sleepiness and its risk factors in incident Parkinson's disease publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2012-304097 – volume: 23 start-page: 35 year: 2008 ident: key-10.1136/jnnp-2016-315023-8 article-title: Nighttime sleep problems and daytime sleepiness in Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.21727 – volume: 30 start-page: 1371 year: 2015 ident: key-10.1136/jnnp-2016-315023-2 article-title: Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study publication-title: Mov Disord doi: 10.1002/mds.26248 – volume: 28 start-page: 715 year: 2013 ident: key-10.1136/jnnp-2016-315023-41 article-title: Neuronal vulnerability, pathogenesis, and Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.25187 – volume: 38 start-page: 589 year: 1995 ident: key-10.1136/jnnp-2016-315023-47 article-title: Decreased single-photon emission computed tomographic [123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease publication-title: Ann Neurol doi: 10.1002/ana.410380407 – volume: 7 start-page: 448 year: 2006 ident: key-10.1136/jnnp-2016-315023-17 article-title: Vigilance troubles in Parkinson's disease: a subjective and objective polysomnographic study publication-title: Sleep Med doi: 10.1016/j.sleep.2005.12.002 – volume: 21 start-page: 710 year: 2012 ident: key-10.1136/jnnp-2016-315023-49 article-title: Progressive dopamine and hypocretin deficiencies in Parkinson's disease: is there an impact on sleep and wakefulness? publication-title: J Sleep Res doi: 10.1111/j.1365-2869.2012.01027.x – year: 2016 ident: key-10.1136/jnnp-2016-315023-4 article-title: A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015 publication-title: Sleep Med Rev – volume: 18 start-page: 1034 year: 2012 ident: key-10.1136/jnnp-2016-315023-46 article-title: Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2012.05.022 – volume: 13 start-page: 377 year: 2013 ident: key-10.1136/jnnp-2016-315023-40 article-title: Cholinergic dysfunction in Parkinson's disease publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-013-0377-9 – volume: 53 start-page: 695 year: 2005 ident: key-10.1136/jnnp-2016-315023-25 article-title: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2005.53221.x – volume: 2 start-page: 841 year: 2008 ident: key-10.1136/jnnp-2016-315023-34 article-title: Random survival forests publication-title: Ann Appl Stat doi: 10.1214/08-AOAS169 – volume: 3 start-page: 482 year: 2016 ident: key-10.1136/jnnp-2016-315023-35 article-title: Predictors of time to initiation of symptomatic therapy in early Parkinson's disease publication-title: Ann Clin Transl Neurol doi: 10.1002/acn3.317 – volume: 20 start-page: 832 year: 2005 ident: key-10.1136/jnnp-2016-315023-5 article-title: Driving in Parkinson's disease: mobility, accidents, and sudden onset of sleep at the wheel publication-title: Mov Disord doi: 10.1002/mds.20412 – volume: 14 start-page: 540 year: 1991 ident: key-10.1136/jnnp-2016-315023-15 article-title: A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale publication-title: Sleep doi: 10.1093/sleep/14.6.540 – volume: 6 start-page: 169 year: 2006 ident: key-10.1136/jnnp-2016-315023-9 article-title: Excessive daytime sleepiness and unintended sleep in Parkinson's disease publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-996-0041-8 – volume: 14 start-page: 40 year: 2014 ident: key-10.1136/jnnp-2016-315023-36 article-title: External validation of multivariable prediction models: a systematic review of methodological conduct and reporting publication-title: BMC Med Res Methodol doi: 10.1186/1471-2288-14-40 – volume: 14 start-page: 169 year: 2006 ident: key-10.1136/jnnp-2016-315023-26 article-title: Test characteristics of the 15-item Geriatric Depression Scale and Hamilton Depression Rating Scale in Parkinson disease publication-title: Am J Geriatr Psychiatry doi: 10.1097/01.JGP.0000192488.66049.4b – volume: 17 start-page: 427 year: 1967 ident: key-10.1136/jnnp-2016-315023-23 article-title: Parkinsonism: onset, progression and mortality publication-title: Neurology doi: 10.1212/WNL.17.5.427 – volume: 27 start-page: 242 year: 2012 ident: key-10.1136/jnnp-2016-315023-29 article-title: Questionnaire for Impulsive-Compulsive disorders in Parkinson's Disease-Rating Scale publication-title: Mov Disord doi: 10.1002/mds.24023 – volume: 17 start-page: 194 year: 2010 ident: key-10.1136/jnnp-2016-315023-27 article-title: Independent validation of the scales for outcomes in Parkinson’s disease-autonomic (SCOPA-AUT) publication-title: Eur J Neurol doi: 10.1111/j.1468-1331.2009.02788.x – volume: 29 start-page: 736 year: 2014 ident: key-10.1136/jnnp-2016-315023-31 article-title: Investigating rapid eye movement sleep without atonia in Parkinson's disease using the rapid eye movement sleep behavior disorder screening questionnaire publication-title: Mov Disord doi: 10.1002/mds.25832 – volume: 67 start-page: 853 year: 2006 ident: key-10.1136/jnnp-2016-315023-12 article-title: Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? publication-title: Neurology doi: 10.1212/01.wnl.0000233980.25978.9d – volume: 26 start-page: 2011 year: 2011 ident: key-10.1136/jnnp-2016-315023-3 article-title: Quality of life in young- compared with late-onset Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.23763 – volume: 25 start-page: 2704 year: 2010 ident: key-10.1136/jnnp-2016-315023-19 article-title: Scales to assess sleep impairment in Parkinson's disease: critique and recommendations publication-title: Mov Disord doi: 10.1002/mds.23190 – volume: 16 start-page: 102 year: 2007 ident: key-10.1136/jnnp-2016-315023-16 article-title: Measurement properties and hierarchical item structure of the Epworth Sleepiness Scale in Parkinson's disease publication-title: J Sleep Res doi: 10.1111/j.1365-2869.2007.00570.x – volume: 11 start-page: 427 year: 2015 ident: key-10.1136/jnnp-2016-315023-37 article-title: Time to response with sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy publication-title: J Clin Sleep Med doi: 10.5664/jcsm.4598 – volume: 24 start-page: 34 year: 2016 ident: key-10.1136/jnnp-2016-315023-6 article-title: Course and risk factors for excessive daytime sleepiness in Parkinson's disease publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2016.01.020 – volume: 23 start-page: 2129 year: 2008 ident: key-10.1136/jnnp-2016-315023-21 article-title: Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results publication-title: Mov Disord doi: 10.1002/mds.22340 – volume: 85 start-page: 162 year: 2015 ident: key-10.1136/jnnp-2016-315023-13 article-title: Development of excessive daytime sleepiness in early Parkinson disease publication-title: Neurology doi: 10.1212/WNL.0000000000001737 – volume: 28 start-page: 668 year: 2013 ident: key-10.1136/jnnp-2016-315023-22 article-title: How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale publication-title: Mov Disord doi: 10.1002/mds.25383 – volume: 173 start-page: 1032 year: 2011 ident: key-10.1136/jnnp-2016-315023-14 article-title: Daytime napping, nighttime sleeping, and Parkinson disease publication-title: Am J Epidemiol doi: 10.1093/aje/kwq478 – volume: 22 start-page: 1839 year: 2007 ident: key-10.1136/jnnp-2016-315023-39 article-title: Prognostic factors for the progression of Parkinson's disease: a systematic review publication-title: Mov Disord doi: 10.1002/mds.21537 – volume: 259 start-page: 318 year: 2012 ident: key-10.1136/jnnp-2016-315023-10 article-title: Widespread cortical and subcortical brain atrophy in Parkinson's disease with excessive daytime sleepiness publication-title: J Neurol doi: 10.1007/s00415-011-6187-6 – volume: 24 start-page: 197 year: 2003 ident: key-10.1136/jnnp-2016-315023-42 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(02)00065-9 – volume: 22 start-page: 2386 year: 2007 ident: key-10.1136/jnnp-2016-315023-30 article-title: The REM sleep behavior disorder screening questionnaire—a new diagnostic instrument publication-title: Mov Disord doi: 10.1002/mds.21740 – volume: 25 start-page: 2649 year: 2010 ident: key-10.1136/jnnp-2016-315023-32 article-title: Systematic review of levodopa dose equivalency reporting in Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.23429 – volume: 26 start-page: 399 year: 2011 ident: key-10.1136/jnnp-2016-315023-1 article-title: The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease publication-title: Mov Disord doi: 10.1002/mds.23462 – volume: 83 start-page: 1253 year: 2014 ident: key-10.1136/jnnp-2016-315023-45 article-title: Predictors of dementia in Parkinson disease: a prospective cohort study publication-title: Neurology doi: 10.1212/WNL.0000000000000842 – volume: 44 start-page: 406 year: 1976 ident: key-10.1136/jnnp-2016-315023-28 article-title: The State-Trait Anxiety Inventory: a systematic evaluation publication-title: J Consult Clin Psychol doi: 10.1037/0022-006X.44.3.406 – volume: 70 start-page: 1277 year: 2013 ident: key-10.1136/jnnp-2016-315023-33 article-title: Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease publication-title: JAMA Neurol – start-page: 152 volume-title: Third Symposium of Parkinson's Disease year: 1969 ident: key-10.1136/jnnp-2016-315023-24 – volume: 31 start-page: 1095 year: 2016 ident: key-10.1136/jnnp-2016-315023-43 article-title: Nonmotor features of Parkinson's disease subtypes publication-title: Mov Disord doi: 10.1002/mds.26510 – volume: 254 start-page: 1037 year: 2007 ident: key-10.1136/jnnp-2016-315023-48 article-title: Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's disease publication-title: J Neurol doi: 10.1007/s00415-006-0483-6 |
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| Snippet | BackgroundExcessive daytime sleepiness (EDS) is common and disabling in Parkinson’s disease (PD). Predictors of EDS are unclear, and data on biological... Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS... Background Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological... |
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| SubjectTerms | Adult Aged Anxiety Case-Control Studies Cross-Sectional Studies Disorders of Excessive Somnolence - chemically induced Disorders of Excessive Somnolence - diagnosis Disorders of Excessive Somnolence - epidemiology Dopamine Dopamine Agents - adverse effects Dopamine Agents - therapeutic use Dose-Response Relationship, Drug Female Humans Longitudinal Studies Male Medical prognosis Middle Aged Neurodegeneration Neurologic Examination - drug effects Parkinson Disease - diagnosis Parkinson Disease - drug therapy Parkinson Disease - epidemiology Parkinson's disease Prognosis Sleep Wake Disorders - diagnosis Sleep Wake Disorders - drug therapy Sleep Wake Disorders - epidemiology Studies |
| Title | Longitudinal assessment of excessive daytime sleepiness in early Parkinson’s disease |
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