Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series

Background/aimsIn order to address the eye care needs of the increasing numbers of elderly Chinese globally, there is a need for comprehensive understanding on the longitudinal trends of age-related eye diseases among Chinese. We herein report the key findings from the baseline Singapore Chinese Eye...

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Published in:British journal of ophthalmology Vol. 104; no. 5; pp. 610 - 615
Main Authors: Majithia, Shivani, Tham, Yih Chung, Chee, Miao Li, Teo, Cong Ling, Chee, Miao-Ling, Dai, Wei, Kumari, Neelam, Lamoureux, Ecosse Luc, Sabanayagam, Charumathi, Wong, Tien Yin, Cheng, Ching-Yu
Format: Journal Article
Language:English
Published: England BMJ Publishing Group LTD 01.05.2020
Subjects:
Adult
Age
Age Distribution
Aged
Aged, 80 and over
Cataracts
China - epidemiology
Cross-Sectional Studies
Diabetic retinopathy
Epidemiology
Eye diseases
Eye Diseases - diagnosis
Eye Diseases - epidemiology
Female
Fluorescein Angiography - methods
Follow-Up Studies
Fundus Oculi
Glaucoma
Humans
Incidence
Macular degeneration
Male
Methods
Middle Aged
Prevalence
Quality of life
Questionnaires
Response rates
Retrospective Studies
Risk Factors
Sex Distribution
Singapore - epidemiology
Surveys and Questionnaires
Time Factors
Tomography, Optical Coherence - methods
Trends
Visual Acuity
Visually Impaired Persons - statistics & numerical data
China
Singapore
United States > US
epidemiology
vision
eye (globe)
ISSN:0007-1161, 1468-2079, 1468-2079
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Summary:Background/aimsIn order to address the eye care needs of the increasing numbers of elderly Chinese globally, there is a need for comprehensive understanding on the longitudinal trends of age-related eye diseases among Chinese. We herein report the key findings from the baseline Singapore Chinese Eye Study (SCES-1), and describe the rationale and methodology of the 6-year follow-up study (SCES-2).Methods3353 Chinese adults who participated in the baseline SCES-1 (2009–2011) were invited for the 6-year follow-up SCES-2 (2015–2017). Examination procedures for SCES-2 included standardised ocular, systemic examinations and questionnaires identical to SCES-1. SCES-2 further included new examinations such as optical coherence tomography angiography, and questionnaires to evaluate health impact and economic burden of eye diseases.ResultsIn SCES-1, the age-adjusted prevalence of best-corrected low vision (VA<6/12, better-seeing eye) and blindness (VA<6/60, better-seeing eye) were 3.4% and 0.2%, respectively. The prevalence rates for glaucoma, age related macular degeneration, and diabetic retinopathy (among diabetics) were 3.2%, 6.8%, 26.2%, respectively. Of the 3033 eligible individuals from SCES-1, 2661 participated in SCES-2 (response rate=87.7%). Comparing with those who did not attend SCES-2, those attended were younger, had higher SES (all p<0.001), but less likely to be a current smoker, to have diabetes, hypertension, hyperlipidaemia (all p≤0.025).ConclusionsBuilding on SCES-1, SCES-2 will be one of the few longitudinal population-based eye studies to report incidence, progression, and risk factors of major age-related eye diseases. Findings from this cohort may offer new insights, and provide useful reference information for other Chinese populations elsewhere.
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ISSN:0007-1161
1468-2079
1468-2079
DOI:10.1136/bjophthalmol-2019-314760