Targeted next-generation sequencing for drug-resistant tuberculosis diagnosis: implementation considerations for bacterial load, regimen selection and diagnostic algorithm placement

IntroductionEarly and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is essential for improving treatment outcomes. Phenotypic drug susceptibility testing (pDST) is comprehensive but slow, while rapid molecular assays provide resistance information for a limited number of drugs. Targeted...

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Bibliographic Details
Published in:	BMJ global health Vol. 10; no. 11; p. e019135
Main Authors:	Georghiou, Sophia B, Tukvadze, Nestani, Rodrigues, Camilla, Omar, Shaheed Vally, Cabibbe, Andrea Maurizio, Seifert, Marva, Uplekar, Swapna, Ismail, Nazir, Ruhwald, Morten, Suresh, Anita, Colman, Rebecca E
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 04.11.2025 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Algorithms Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Diagnostics and tools Drug resistance Global Health High-Throughput Nucleotide Sequencing - methods Humans Microbial Sensitivity Tests - methods Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Original research Other diagnostic or tool Respiratory infections Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Whole genome sequencing Tuberculosis Global Health Other diagnostic or tool Diagnostics and tools Respiratory infections
ISSN:	2059-7908, 2059-7908
Online Access:	Get full text
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