Commentary on differential impact of TIM-3 ligands on NK cell function

T-cell immunoglobin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor and a target for immune checkpoint blockers (ICBs). Unfortunately in human patients the success rate of anti-TIM-3 ICB remains rather limited. Multiple immune cells express TIM-3 and their functioning...

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Vydáno v:Journal for immunotherapy of cancer Ročník 13; číslo 7; s. e012125
Hlavní autor: van de Ven, Rieneke
Médium: Journal Article
Jazyk:angličtina
Vydáno: England BMJ Publishing Group Ltd 11.07.2025
BMJ Publishing Group LTD
BMJ Publishing Group
Témata:
Apoptosis
Cancer
Clinical trials
Commentary
Cytotoxicity
Disease
Galectins - metabolism
Head and Neck Cancer
Hepatitis A Virus Cellular Receptor 2 - metabolism
Human papillomavirus
Humans
Immune Checkpoint Inhibitor
Immune modulatory
Immunotherapy
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Ligands
Medical prognosis
Natural killer - NK
Proteins
Squamous cell carcinoma
Tumors
Immune modulatory
Head and Neck Cancer
Natural killer - NK
Immune Checkpoint Inhibitor
ISSN:2051-1426, 2051-1426
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Shrnutí:T-cell immunoglobin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor and a target for immune checkpoint blockers (ICBs). Unfortunately in human patients the success rate of anti-TIM-3 ICB remains rather limited. Multiple immune cells express TIM-3 and their functioning is affected by receptor–ligand interactions. Four ligands of TIM-3 have been identified: high-mobility group protein B1, galectin-9, phosphatidylserine and carcinoembryonic antigen cell adhesions molecule 1. Wang et al investigated which of these ligands interact with TIM-3 on natural killer (NK) cells, impairing NK cytotoxicity and proliferation. They demonstrated that galectin-9 was able to inhibit NK cell cytotoxicity in a TIM-3-dependent manner, and to block NK cell proliferation through interaction with CD44 on NK cells. They also showed that in head and neck squamous cell carcinoma (HNSCC), a high TIM-3+NK cell transcriptional signature was linked to poor survival probability, specifically in HNSCC caused by human papillomavirus infection. This study enhances our understanding of why anti-TIM-3 ICB may not be so effective as monotherapy and provides leads toward rational design of combination strategies and patient selection.
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ISSN:2051-1426
2051-1426
DOI:10.1136/jitc-2025-012125