A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Background: Herbal medicines long have been used in the management of diabetes mellitus (DM). Objective: This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy. Metho...
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| Vydáno v: | African health sciences Ročník 19; číslo 1; s. 1594 - 1601 |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Uganda
Makerere University Medical School
01.03.2019
Makerere Medical School |
| Témata: | |
| ISSN: | 1680-6905, 1729-0503, 1680-6905, 1729-0503 |
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| Abstract | Background: Herbal medicines long have been used in the management of
diabetes mellitus (DM). Objective: This study was conducted to
ascertain if fenugreek compared with glibenclamide had any impacts on
controlling blood glucose in patients with uncontrolled type II DM on
conventional therapy. Methods: A total of 12 patients with uncontrolled
DM and on metformin were recruited and divided into two groups.
Patients in group 1 received 2 g fenugreek per day, whereas those in
group 2 received glibenclamide 5 mg once daily. The impacts of
fenugreek on the glycemic control and lipid profile were measured
before initiation of the regimen and then after 12 weeks. Results: Only
9 of the 12 study participants completed the study. Fenugreek at 2
g/day caused an insignificant drop in fasting blood glucose (P = 0.63),
but the fasting insulin level increased significantly (P = 0.04). The
ratio of high- to low-density lipoprotein was significantly decreased
from before to after treatment (P = 0.006). Fenugreek did not cause any
notable adverse impacts on hepatic and renal functions throughout the
study. Conclusion: Fenugreek could be used as adjuvant therapy to
anti-diabetic drugs to control blood glucose, and further studies are
needed. DOI: https://dx.doi.org/10.4314/ahs.v19i1.34 Cite as: Najdi
RA, Hagras MM, Kamel FO, RM M. A randomized controlled clinical trial
evaluating the effect of Trigonella foenum-graecum (fenugreek) versus
glibenclamide in patients with diabetes. Afri Health Sci. 2019;19(1).
1594-1601. https://dx.doi.org/10.4314/ahs.v19i1.34 |
|---|---|
| AbstractList | Herbal medicines long have been used in the management of diabetes mellitus (DM).
This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy.
A total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks.
Only 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipoprotein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study.
Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed. Herbal medicines long have been used in the management of diabetes mellitus (DM).BACKGROUNDHerbal medicines long have been used in the management of diabetes mellitus (DM).This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy.OBJECTIVEThis study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy.A total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks.METHODSA total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks.Only 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipoprotein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study.RESULTSOnly 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipoprotein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study.Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed.CONCLUSIONFenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed. Background: Herbal medicines long have been used in the management of diabetes mellitus (DM). Objective: This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy. Methods: A total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks. Results: Only 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipoprotein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study. Conclusion: Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed. DOI: https://dx.doi.org/10.4314/ahs.v19i1.34 Cite as: Najdi RA, Hagras MM, Kamel FO, RM M. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes. Afri Health Sci. 2019;19(1). 1594-1601. https://dx.doi.org/10.4314/ahs.v19i1.34 |
| Author | Najdi, Rania A Hagras, Magda M Kamel, Fatemah O Magadm, Rania M |
| AuthorAffiliation | 1 Pharmacology Department, Faculty of Medicine, KAU, Jeddah, Saudi Arabia 2 Pharmacology department, Faculty of Medicine, Suez Canal University, Egypt |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31148988$$D View this record in MEDLINE/PubMed |
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| Keywords | diabetes glibenclamide Trigonella foenum-graecum (fenugreek) |
| Language | English |
| License | Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Email addresses: Rania A Najdi (rania.magadmi@yahoo.com); Magda M Hagras, MBBS PhD (Magyhagras@hotmail.com); Fatemah O Kamel, MBBS MSc PhD (fokamel@kau.edu.sa); Rania M Magadmi, MBBS PhD (rmagadmi@kau.edu.sa). |
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| Snippet | Background: Herbal medicines long have been used in the management of
diabetes mellitus (DM). Objective: This study was conducted to
ascertain if fenugreek... Herbal medicines long have been used in the management of diabetes mellitus (DM). This study was conducted to ascertain if fenugreek compared with... Herbal medicines long have been used in the management of diabetes mellitus (DM).BACKGROUNDHerbal medicines long have been used in the management of diabetes... |
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| SubjectTerms | Adult Aged Blood Glucose - drug effects Blood Glucose - metabolism diabetes Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - drug therapy Dose-Response Relationship, Drug Female glibenclamide Glyburide - chemistry Glycated Hemoglobin A - drug effects Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Lipids - blood Male Middle Aged Phytotherapy - methods Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Seeds Treatment Outcome Trigonella - chemistry Trigonella foenum-graecum (fenugreek) |
| Title | A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes |
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