A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes

Background: Herbal medicines long have been used in the management of diabetes mellitus (DM). Objective: This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy. Metho...

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Veröffentlicht in:African health sciences Jg. 19; H. 1; S. 1594 - 1601
Hauptverfasser: Najdi, Rania A, Hagras, Magda M, Kamel, Fatemah O, Magadm, Rania M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Uganda Makerere University Medical School 01.03.2019
Makerere Medical School
Schlagworte:
Adult
Aged
Blood Glucose - drug effects
Blood Glucose - metabolism
diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - drug therapy
Dose-Response Relationship, Drug
Female
glibenclamide
Glyburide - chemistry
Glycated Hemoglobin A - drug effects
Humans
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Lipids - blood
Male
Middle Aged
Phytotherapy - methods
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Seeds
Treatment Outcome
Trigonella - chemistry
Trigonella foenum-graecum (fenugreek)
diabetes
glibenclamide
Trigonella foenum-graecum (fenugreek)
ISSN:1680-6905, 1729-0503, 1680-6905, 1729-0503
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Zusammenfassung:Background: Herbal medicines long have been used in the management of diabetes mellitus (DM). Objective: This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy. Methods: A total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks. Results: Only 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipoprotein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study. Conclusion: Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed. DOI: https://dx.doi.org/10.4314/ahs.v19i1.34 Cite as: Najdi RA, Hagras MM, Kamel FO, RM M. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes. Afri Health Sci. 2019;19(1). 1594-1601. https://dx.doi.org/10.4314/ahs.v19i1.34
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Email addresses: Rania A Najdi (rania.magadmi@yahoo.com); Magda M Hagras, MBBS PhD (Magyhagras@hotmail.com); Fatemah O Kamel, MBBS MSc PhD (fokamel@kau.edu.sa); Rania M Magadmi, MBBS PhD (rmagadmi@kau.edu.sa).
ISSN:1680-6905
1729-0503
1680-6905
1729-0503
DOI:10.4314/ahs.v19i1.34